Back to results
US 6,784,188 B2Granted
Urea substituted imidazoquinolines
Assignee3M Innovative Properties Company
InventorsStephen L. Crooks, George W. Griesgraber, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
Life of this patent
Estimating the term…
Abstract
Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
Claims13
A compound of the formula (I):
- wherein
- bonds represented by the dashed lines are present or absent;
- R1 is —C2-6 alkyl-NR3—CY—NR5—R4 wherein Y is ═O;
- R4 is alkyl or aryl;
- R2 is selected from the group consisting of:
- —C1-4 alkyl and
- —C1-4 alkyl-O—C1-4 alkyl;
- R3 is hydrogen;
- R5 is hydrogen;
- and
- n is 0;
- or a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.