Piperazine-containing compounds useful in the treatment of pain
AssigneeAstraZeneca AB
InventorsWilliam Brown, Christopher Walpole, Niklas Plobeck
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Abstract
The present invention is directed to a compound of general formula (I), wherein R1 is selected from phenyl, pyridinyl, thiophenyl, furanyl, imidazolyl; each phenyl ring and heteroaromatic ring optionally and independently being further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo, as well as their pharmaceutically acceptable salts. The invention includes pharmaceutical compositions comprising these compounds and the use of the compounds in therapy, in particular in the management of pain.
Claims22
A compound according to formula I
- wherein
- R1 is selected from
- (i) phenyl;
- (ii) pyridinyl
- (iii) thiophenyl
- (iv) furanyl
- (v) imidazolyl
- (vi) triazolyl
- where each phenyl ring and heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo;
- as well as pharmaceutically acceptable salts thereof and enantiomers thereof.
A compound according to any of the preceding claims, in form of its hydrochloride, sulfate, tartrate or citrate salts.
A compound selected from the group consisting of:
- (+)4-[(4-benzyl-1-piperazinyl)(8-quinolinyl)methyl]-N,N-diethylbenzamide;
- and
- (+)4-[[4-(4-methylbenzyl)-1-piperazinyl](8-quinolinyl)methyl]-N,N-diethylbenzamide.
A compound selected from the group consisting of:
- (−)4-[(4-benzyl-1-piperazinyl)(8-quinolinyl)methyl]-N,N-diethylbenzamide;
- and
- (−)4-[[4-(4-methylbenzyl)-1-piperazinyl](8-quinolinyl)methyl]-N,N-diethylbenzamide.
Dependencies are inferred from the claim text.