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US 6,784,177 B2Granted
Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
AssigneeNitro Med, Inc.
InventorsJay N. Cohn, Peter Carson
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AssigneeNitro Med, Inc.
InventorsJay N. Cohn, Peter Carson
Estimating the term…
The present invention provides methods of treating and preventing mortality associated with heart failure in an African American patient with hypertension, and improving oxygen consumption, quality of life and exercise tolerance by administering a therapeutically effective amount of at least one hydralazine compound and at least one of isosorbide dinitrate and isosorbide mononitrate, and, optionally, one or more compounds, such as, for example, a digitalis, a diuretic compound, or a compound used to treat cardiovascular diseases. In the present invention, the hydralazine compound is preferably hydralazine or a pharmaceutically acceptable salt thereof. Preferred methods of the invention comprise administering hydralazine or a pharmaceutically acceptable salt thereof and isosorbide dinitrate.
A method of reducing mortality associated with heart failure in a black patient in need thereof comprising administering to the black patient hydralazine or a pharmaceutically acceptable salt thereof in an amount of about 30 milligrams per day to about 300 milligrams per day and isosorbide dinitrate in an amount of about 20 milligrams per day to about 200 milligrams per day.
A method for improving oxygen consumption in a black patient in need thereof comprising administering to the black patient hydralazine or a pharmaceutically acceptable salt thereof in an amount of about 30 milligrams per day to about 300 milligrams per day and isosorbide dinitrate in an amount of about 20 milligrams per day to about 200 milligrams per day.
A method of reducing mortality associated with heart failure in a black patient comprising administering to the black patient a therapeutically effective amount of:
A method for improving oxygen consumption in a black patient in need thereof comprising administering to the black patient a therapeutically effective amount of:
A method for reducing mortality associated with heart failure in a black patient in need thereof comprising administering to the black patient hydralazine or a pharmaceutically acceptable salt thereof in an amount of about 30 milligrams per day to about 300 milligrams per day and isosorbide mononitrate in an amount of about 10 milligrams to about 120 milligrams per day.
A method for improving oxygen consumption in a black patient in need thereof comprising administering to the black patient hydralazine or a pharmaceutically acceptable salt thereof in an amount of about 30 milligrams per day to about 300 milligrams per day and isosorbide mononitrate in an amount of about 10 milligrams to about 120 milligrams per day.
A method for treating hypertension in a black patient in need thereof comprising administering to the black patient a therapeutically effective amount of:
A method for treating hypertension in a black patient in need thereof comprising administering to the black patient hydralazine or a pharmaceutically acceptable salt thereof in an amount of about 30 milligrams per day to about 300 milligrams per day and isosorbide dinitrate in an amount of about 20 milligrams per day to about 200 milligrams per day.
A method for treating hypertension in a black patient in need thereof comprising administering to the black patient hydralazine or a pharmaceutically acceptable salt thereof in an amount of about 30 milligrams per day to about 300 milligrams per day and isosorbide mononitrate in an amount of about 10 milligrams per day to about 120 milligrams per day.
A method for improving exercise tolerance or for improving the quality of life in a black patient in need thereof comprising administering to the black patient a therapeutically effective amount of:
A method for improving exercise tolerance or for improving the quality of life in a black patient in need thereof comprising administering to the black patient hydralazine or a pharmaceutically acceptable salt thereof in an amount of about 30 milligrams per day to about 300 milligrams per day and isosorbide dinitrate in an amount of about 20 milligrams per day to about 200 milligrams per day.
A method for improving exercise tolerance or for improving the quality of life in a black patient in need thereof comprising administering to the black patient hydralazine or a pharmaceutically acceptable salt thereof in an amount of about 30 milligrams per day to about 300 milligrams per day and isosorbide mononitrate in an amount of about 10 milligrams per day to about 120 milligrams per day.
A method for treating heart failure in a black patient in need thereof comprising administering to the black patient a therapeutically effective amount of:
A method for treating heart failure in a black patient in need thereof comprising administering to the black patient hydralazine or a pharmaceutically acceptable salt thereof in an amount of about 30 milligrams per day to about 300 milligrams per day and isosorbide dinitrate in an amount of about 20 milligrams per day to about 200 milligrams per day.
A method for treating heart failure in a black patient in need thereof comprising administering to the black patient hydralazine or a pharmaceutically acceptable salt thereof in an amount of about 30 milligrams per day to about 300 milligrams per day and isosorbide mononitrate in an amount of about 10 milligrams per day to about 120 milligrams per day.
Dependencies are inferred from the claim text.