A bicyclic compound of the Formula (I):
- wherein:
- G is N;
- the bicyclic ring formed by the fusion of ring X to the adjacent nitrogen-containing 6-membered heteroaryl ring within Formula (I) is furopyrimidinyl, thienopyrimidinyl, pyrrolopyrimidinyl, oxazolopyrimidinyl, thiazolopyrimidinyl, purinyl, pyridopyrimidinyl, pyrimidopyrimidinyl or pteridinyl;
- m is 0 or 1;
- R1 is hydroxy, halo, C1-6alkyl, C1-6alkoxy, C1-6alkylS(O)n— (wherein n is 0-2), N,N-(C1-6alkyl)2aminoC1-6alkyl, N,N-(C1-6alkyl)2carbamoylC1-6alkoxy, N,N-(C1-6alkyl)2aminoC1-6alkoxy, C1-6alkylS(O)2—C1-6alkoxy, N,N-(C1-6alkyl)2amino-N-(C1-6alkyl)C1-6alkylamino, N,N-(C1-6alkyl)2aminoC1-6alkylaminoC1-6alkyl, piperidin-1-ylC1-6alkyl, homopiperidin-1-ylC1-6alkyl, N-(C1-6alkyl)piperidin-1-ylC1-6alkyl, N-(C1-6alkyl) homopiperidin-1-ylC1-6alkyl, piperazin-1-ylC1-6alkyl, 4-C1-6alkylpiperazin-1-ylC1-6alkyl, homopiperazinyl-1-ylC1-6alkyl, 4-C1-6alkylhomopiperazinyl-1-ylC1-6alkyl, pyrrolidinylC1-6alkoxy, piperidinylC1-6alkoxy, homopiperidinylC1-6alkoxy, N-(C1-6alkyl)pyrrolidinylC1-6alkoxy, N-(C1-6alkyl)piperidinylC1-6alkoxy, N-(C1-6alkyl)homopiperidinylC1-6alkoxy, morpholinylC1-6alkoxy, piperazinylC1-6alkoxy, N-(C1-6alkyl)piperazinylC1-6alkoxy, homopiperazinylC1-6alkoxy, N-(C1-6alkyl)homopiperazinylC1-6alkoxy, pyrrolidinyloxy, N-1-6alkyl)pyrrolidinyloxy, piperidinyloxy, N-(C1-6alkyl)piperidinyloxy, homopiperidinyloxy, N-(C1-6alkyl)homopiperidinyloxy, morpholinylC1-6alkylaminoC1-6alkyl, thiazolylC1-6alkoxy or pyridylC1-6alkoxy;
- and any aryl, heteroaryl or heterocyclyl group in a R1 group may be optionally substituted with one or more groups selected from hydroxy, halo, C1-6alkyl, C1-6alkoxy, carboxy, C1-6alkoxycarbonyl, carbamoyl, N-C1-6alkylcarbamoyl, N-(C1-6alkyl)2 carbamoyl, C2-6alkanoyl, amino, N-C1-6alkylamino and N,N-(C1-6alkyl)2amino,
- and any heterocyclyl group in a R1 group may be optionally substituted with one or two oxo or thioxo substituents,
- and any of the R1 groups defined hereinbefore which comprises a CH2 group which is attached to 2 carbon atoms or a CH3 group which is attached to a carbon atom may optionally bear on each said CH2 or CH3 group a substituent selected from hydroxy, amino, C1-6alkoxy, N-C1-6alkylamino, N,N-(C1-6alkyl)2amino and heterocyclyl;
- R2 is hydrogen, C1-4alkyl or halo;
- R3 is hydrogen, C1-4alkyl or halo;
- q is 0;
- R4 is phenyl, thienyl, furyl, oxazolyl, isoxazolyl, pyrimidyl or pyridyl optionally substituted by one or two halo, trifluoromethyl, cyano, C1-4alkyl, C1-4alkoxy, —O—(C1-3alkyl)—O—, N,N-(C1-4alkyl)2amino, C1-6alkanoylamino, C1-6alkylsulphonyl-N-(C1-6alkyl)amino, phenyl (optionally substituted by one or two halo groups), furyl, azetidinyl, pyrrolidinyl, 3-pyrrolinyl, piperidinyl, homopiperidinyl, morpholino, piperazinyl, homopiperazinyl, N-(C1-6alkyl)piperazinyl and N-(C1-6alkyl)homopiperazinyl, or R4 is fluorenyl or dibenzofuranyl;
- and any aryl, heteroaryl or heterocyclyl group in a R4 group may be optionally substituted by one or more groups selected from hydroxy, halo, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy, carbamoyl, formyl, sulphamoyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, —O—(C1-3alkyl)—O—, C1-6alkylS(O)n— (wherein n is 0-2), N-C1-6alkylamino, N,N-(C1-6alkyl)2amino, C1-6alkoxycarbonyl, N-C1-6alkylcarbamoyl, N,N-(C1-6alkylcarbamoyl, C2-6alkanoyl, C1-6alkanoyloxy, C1-6alkanoylamino, N-C1-6alkylsulphamoyl, N,N-(C1-6alkyl)2sulphamoyl, C1-6alkylsulphonylamino and C1-6alkylsulphonyl-N-(C1-6alkyl)amino,
- or any aryl, heteroaryl or heterocyclyl group in a R4 group may be optionally substituted with one or more groups of the Formula (IA′):
- —B1—(CH2)p—A1 (IA′)
- wherein A1 is halo, hydroxy, C1-6alkoxy, cyano, amino, N-C1-6alkylamino, N,N-(C1-6alkyl)2amino, carboxy, C1-6alkoxycarbonyl, carbamoyl, N-C1-6alkylcarbamoyl or N,N-(C1-6alkyl)2carbamoyl, p is 1-6, and B1 is a bond, oxy, imino, N-(C1-6alkyl)imino or —NHC(O)—, with the proviso that p is 2 or more unless B1 is a bond or —NHC(O)—,
- or any aryl, heteroaryl or heterocyclyl group in a R4 group may be optionally substituted with one or more groups of the Formula (IB′):
- —E1—D1 (IB′)
- wherein D1 is aryl, heteroaryl or heterocyclyl and E1 is a bond, C1-6alkylene, oxyC1-6alkylene, oxy, imino, N-(C1-6alkyl)imino, iminoC1-6alkylene, N-(C1-6alkyl)iminoC1-6alkylene, C1-6alkylene-oxyC1-6alkylene, C1-6alkylene-iminoC1-6alkylene, C1-6alkylene-N-(C1-6alkyl)-iminoC1-6alkylene, —NHC(O)—, —NHSO2—, —SO2NH— or —NHC(O)-C1-6alkylene-,
- and any aryl, heteroaryl or heterocyclyl group in a substituent on R4 may be optionally substituted with one or more groups selected from hydroxy, halo, C1-6alkyl, C1-6alkoxy, carboxy, C1-6alkoxycarbonyl, carbamoyl, N-C1-6alkylcarbamoyl, N-(C1-6alkyl)2carbamoyl, C2-6alkanoyl, amino, N-C1-6alkylamino and N,N-(C1-6alkyl)2amino,
- and any C3-7cycloalkyl or heterocyclyl group in a R4 group may be optionally substituted with one or two oxo or thioxo substituents,
- and any of the R4 groups defined hereinbefore which comprises a CH2 group which is attached to 2 carbon atoms or a CH3 group which is attached to a carbon atom may optionally bear on each said CH2 or CH3 group a substituent selected from hydroxy, amino, C1-6alkoxy, N-C1-6alkylamino, N,N-(C1-6alkyl)2amino and heterocyclyl;
- and
- R5 is hydrogen;
- or a pharmaceutically acceptable salt or an in vivo cleavable ester thereof.