Method of use of erythropoietin to treat ischemic acute renal failure
AssigneeUniversity of Utah Research Foundation
InventorChristof Westenfelder
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Abstract
Recombinant erythropoietin is used in a method to prevent ischemic acute renal failure in patients at risk for developing ischemic acute renal failure and to treat fully-developed ischemic acute renal failure. The method is also used to prevent harmful cell apoptosis in renal tubular cells and to stimulate mitogenesis and motogenesis in renal tubular cells. The method comprises the administration of a composition of recombinant erythropoietin in a pharmacologically acceptable carrier to a patient for the purpose of preventing the development of ischemic acute renal failure, treating established acute renal failure, preventing harmful cell apoptosis in renal tubular cells.
Claims21
A method of renoprotection in an individual at risk for developing ischemic acute renal failure comprising administering a composition prior to the individual developing ischemic acute renal failure, said composition comprising a therapeutically effective amount of erythropoietin and a pharmaceutically acceptable carrier, for a time and under conditions effective for renoprotection.
A method of treating ischemic acute renal failure in an individual at risk for developing ischemic acute renal failure comprising administering a composition prior to the individual developing ischemic acute renal failure, said composition comprising a therapeutically effective amount of erythropoietin and a pharmaceutically acceptable carrier, for a time and under conditions effective for renoprotection during ischemic acute renal failure.
Dependencies are inferred from the claim text.