Methods of homing molecules to lung using membrane dipeptidase
AssigneeThe Burnham Institute
InventorsDaniel Rajotte, Renata Pasqualini, Erkki Ruoslahti
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Abstract
The present invention provides a method of identifying a membrane dipeptidase (MDP)-binding homing molecule that selectively homes to lung endothelium. The method includes the steps of contacting MDP with one or more molecules; and determining specific binding of a molecule to the MDP, where the presence of specific binding identifies the molecule as a MDP-binding homing molecule that selectively homes to lung endothelium. Such MDP-binding homing molecules can be linked to a moiety and, when administered to a subject as a conjugate, can selectively direct the moiety to lung endothelium in the subject.
Claims11
A method of selectively directing a moiety to lung endothelium in a subject, comprising administering to said subject a conjugate comprising a moiety linked to a MDP-binding homing molecule,
- wherein said MDP-binding homing molecule is identified by a method comprising contacting membrane dipeptidase (MDP) with one or more molecules and determining specific binding of a molecule to said MDP,
- wherein said moiety is selectively directed to lung endothelium in said subject,
- and wherein said homing molecule has the ability to specifically bind the MDP classified as EC 3.4.13.19.
Dependencies are inferred from the claim text.