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US 6,783,973 B1Granted
Mammalian catecholamine receptor genes and uses
AssigneeOregon Health & Science University
InventorsJames R. Bunzow, David K. Grandy
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AssigneeOregon Health & Science University
InventorsJames R. Bunzow, David K. Grandy
Estimating the term…
The present invention relates to novel mammalian catecholamine receptor proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian catecholamine receptor proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to rat and human homologues of a mammalian catecholarnine receptor gene. Also provided are recombinant expression constructs capable of expressing the mammalian catecholamine receptor genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian catecholamine receptor proteins encoded therein. The invention also provides methods for screening compounds in vitro that are capable of binding to the mammalian catecholamine receptor proteins of the invention, and further characterizing the binding properties of such compounds in comparison with known catecholamine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.
An isolated nucleic acid comprising a nucleotide sequence encoding a mammalian catecholamine receptor, wherein the mammalian catecholamine receptor is a human catecholamine receptor and the nucleic acid encodes an amino acid sequence identified by SEQ ID No.:2.
An isolated nucleic acid comprising a nucleotide sequence identified by SEQ ID NO:
An isolated nucleic acid comprising a nucleotide sequence encoding a mammalian catecholamine receptor that hybridizes to a nucleic acid having a nucleotide sequence identified by SEQ ID NO:
An isolated nucleic acid comprising a nucleotide sequence encoding a mammalian catecholamine receptor that hybridizes to a nucleic acid having a nucleotide sequence identified by SEQ ID NO:
Dependencies are inferred from the claim text.