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US 6,783,954 B2Granted
VEGF nucleic acid and amino acid sequences
AssigneeCompugen Ltd.
InventorsLiat Mintz, Kinneret Savitzky, Sharon Engel
Life of this patent
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Abstract
The invention concerns novel nucleic acid sequences and amino acid sequences of a novel variant of vascular endothelial growth factor (VEGF). The invention further concerns expression vectors and host cells containing said sequences as well as pharmaceutical compositions and detection methods using said sequences.
Claims8
An isolated nucleic acid molecule consisting of a polynucleotide having a nucleotide sequence selected from the group consisting of:
- (a) the nucleotide sequence of SEQ ID NO:
- 1;
- (b) a nucleotide sequence encoding the amino acid sequence of SEQ ID NO.2;
- and
- (c) a nucleic acid sequence that is complementary to the nucleic acid sequence of SEQ ID NO:
- 1.
3 more elements
A method for detecting a Vascular Endothelial Growth Factor Variant nucleic acid sequence in a biological sample, comprising the steps of:
- (i) contacting a probe nucleic acid consisting of a nucleotide sequence of SEQ ID NO:1, or a sequence complementary thereto, with a biological sample under conditions such that the probe nucleic acid will hybridize to complementary nucleic acids if present in the sample to form a hybridization complex;
- and
- (ii) detecting said hybridization complex.
Dependencies are inferred from the claim text.