US 6,783,945 B2 · Cloning and uses of the genetic locus bcl-6

Abstract

This invention provides an isolated vertebrate nucleic acid molecule the bcl-6 locus. This invention also provides an isolated human nucleic acid molecule of bcl-6 locus. This invention further provides a nucleic acid molecule comprising a nucleic acid molecule of at least 15 nucleotides capable of specifically hybridizing with a sequence included within the sequence of the nucleic acid molecule of bcl-6 locus. This invention provides an isolated vertebrate nucleic acid molecule of bcl-6 operatively linked to a promoter of RNA transcription. This invention provides a vector which comprises the nucleic acid molecule of bcl-6 locus. This invention provides a host vector system for the production of a polypeptide encoded by bcl-6 locus, which comprises the vector of bcl-6 locus in a suitable host. This invention provides a polypeptide encoded by the isolated vertebrate nucleic acid molecule of bcl-6 locus. This invention provides an antibody capable of binding to polypeptide encoded by bcl-6 locus. This invention provides an antagonist capable of blocking the expression of the polypeptide encoded by bcl-6. This invention provides an antisense molecule capable of hybridizing to the nucleic acid molecule of bcl-6. This invention provides an assay for non-Hodgkin's lymphoma, a method for screening putative therapeutic agents for treatment of non-Hodgkin's lymphoma and a method for diagnosing B-cell lymphoma in a subject. Finally, this invention provides a method of treating a subject with non-Hodgkin's lymphoma.

Claims1

Dependent claims

An assay for detecting the presence of bcl-6 in a tumor suspected of being a Non-Hodgkin's lymphoma comprising:

(a) contacting a sample of the tumor with an antibody that binds to a polypeptide having the sequence set forth in SEQ ID NO:2;
and
(b) determining whether the antibody binds to the tumor sample, thereby determining whether the polypeptide is present in the tumor sample, the presence of the polypeptide indicating that bcl-6 is present in the tumor.

Dependencies are inferred from the claim text.

Facts

Application

09/761,117Filed 16 Jan 2001 · division

Priority

9 Jun 1993

Published

US 2001/0012887 A19 Aug 2001

Granted

31 Aug 2004

Term ends

Not estimatedThe source records don’t support an estimate.

Classification4 codes

C07K 14/82
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: translation products from oncogenes
Y10S 436/813
Test for named disease, body condition or organ function: cancer
C07K
Peptides
Y10S
Technical subjects covered by former uspc cross-reference art collections [xracs] and digests

Family

Application08/074,967Parent of this continuation-in-part · filed 9 Jun 1993

PCT/US94/06669Parent of this continuation · filed 9 Jun 1994

Application08/553,541Parent of this division · filed 28 May 1996

US 5,641,672 AParent of this continuation-in-part · filed 24 Jun 1997

Application09/268,202Parent of this division · filed 15 Mar 1999

US 5,882,858 AParent of this division · filed 16 Mar 1999

US 6,174,997 B1Parent of this division · filed 16 Jan 2001

US 2001/0012887 A1Pre-grant publication · published 9 Aug 2001

Application08/553,541Parent of this continuation

PCT/US94/06669Parent of this continuation-in-part

US 6,783,945 B2This patent

From the US filing history. Foreign family members aren’t listed.

Cloning and uses of the genetic locus bcl-6

Life of this patent

Cloning and uses of the genetic locus bcl-6

Life of this patent

Abstract

Claims1