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US 6,783,937 B1Granted
Negatively charged membrane
AssigneePall Corporation
InventorsChung-Jen Hou, Peter Konstantin, Yujing Yang
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AssigneePall Corporation
InventorsChung-Jen Hou, Peter Konstantin, Yujing Yang
Estimating the term…
The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.
A negatively charged microporous membrane comprising a porous substrate and a crosslinked coating, wherein the crosslinked coating is prepared from a solution comprising a polysaccharide and an anionic polymer, the anionic polymer being obtained by polymerizing a mixture comprising an unsaturated monomer having a negatively charged group, a hydrophilic non-ionic unsaturated monomer, and at least one or more N-(hydroxyalkyl)- or N-(alkoxyalkyl)-acrylamide monomers, wherein the crosslinked coating comprises amide-ester and amide-amide crosslinks.
A process for preparing a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having negatively charged groups, the process comprising:
A process for preparing a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having negatively charged groups, the process comprising:
Dependencies are inferred from the claim text.