Method and apparatus for the coating of substrates for pharmaceutical use
AssigneePhoqus Pharmaceuticals Limited
InventorsSteven R. Brown, Linda A. Reeves, John N. Staniforth
Life of this patent
Estimating the term…
Abstract
Method of coating a substrate which is a belt, sheet, film, or tape, comprising applying an active coating material to the substrate to form an active coating layer, the active coating material comprising biologically active material. The active coating material is applied electrostatically as a powder and, after the active coating material is applied, the active coating material is fused to form an active film layer. The active coating material is removable from the substrate as a wafer comprising the active film layer.
Claims118
A method of coating substrate which is a belt sheet, film, or tape, the method comprising the step of preparing a pharmaceutical product by applying an active coating material to the substrate to form an active coating layer, the active coating material comprising biologically active material, wherein the active coating material is applied electrostatically as a powder, and, after the active coating material is applied, the active coating material is fused to form an active film layer, wherein the active coating material is removable from the substrate as a wafer comprising the active film layer, and wherein the active coating layer is divided into portions.
A method of coating a substrate which is a belt, sheet, film, or tape, the method comprising the step of preparing a pharmaceutical product by applying one or more coating layers to the substrate, the layer or the first layer being applied directly to a surface of the substrate, the layer or at least one of the layers comprising active coating material, the active coating material comprising biologically active material, wherein the active coating material is applied electrostatically as a powder and after the active coating material is applied the active coating material is fused to form an active film layer, wherein the layer or layers applied are removable from the substrate as a coherent layer or layers, and wherein the layer or layers applied are divided into portions.
A method of coating a substrate using a coating apparatus having a conveying surface, the method comprising the steps of preparing a pharmaceutical product by applying an active coating material to the substrate to form an active coating layer, said substrate being the conveying surface of the coating apparatus, the active coating material comprising biologically active material, wherein the active coating material is applied electrostatically as a powder, and, after the active coating material is applied, the active coating material is fused to form an active film layer, and wherein the active coating material is removable from the substrate as a wafer comprising the active film layer, and wherein the active material is removed as a wafer comprising the active film layer and divided into portions.
A method of coating a substrate using a coating apparatus having a conveying surface, the method comprising of the steps of preparing a pharmaceutical product by applying one or more coating layers to the substrate, the layer or the first layer being applied directly to a surface of the substrate, the layer or at least one of the layers comprising active coating material, said substrate being the conveying surface of the coating apparatus, the active coating material comprising biologically active material, wherein the active coating material is applied electrostatically as a powder, and wherein after the active coating material is applied the active coating material is fused to form an active film layer, and wherein the layer or layers applied are removable from the substrate as a coherent layer or layers, and wherein the active coating is removed from the substrate as a coherent layer or layers and the layer or layers are divided into portions.
A method of coating a plurality of coating regions onto the surface of a substrate which is a belt, sheet, film, or tape, the method comprising the step of preparing a pharmaceutical product by:
- (a) applying an active coating material to the substrate to form a plurality of active coating regions comprising active coating layers, the active coating material comprising biologically active material and being applied electrostatically as a powder wherein after the active coating material is applied the active coating material is fused to form regions of active film coating,
- (b) applying a cover coating material to a surface of the substrate to form a plurality of cover coating regions, the cover coating regions forming layers of cover coating material, each active coating region being substantially completely covered by a cover coating region, wherein each region of active coating and cover coating is removable from the substrate as a wafer comprising the active film coating and the cover coating, and
- (c) dividing to form individual dosage units.
A method of coating a plurality of coating regions onto the surface of a substrate using a coating apparatus having a conveying surface, the method comprising the steps of preparing a pharmaceutical product by:
- (a) applying an active coating material to the substrate to form a plurality of active coating regions comprising active coating layers, said substrate being the conveying surface of the coating apparatus, the active coating material comprising biologically active material and being applied electrostatically as a powder wherein after the active coating material is applied the active coating material is fused to form regions of active film coating,
- (b) applying a cover coating material to a surface of the substrate to form a plurality of cover coating regions, the cover coating regions forming layers of cover coating material, each active coating region being substantially completely covered by a cover coating region, wherein each region of active coating and cover coating is removable from the surface of the substrate as a wafer comprising the active film coating and the cover coating, and wherein the active coating regions are removed as wafers each comprising the active film coating the cover coating, and divided into portions.
A method of coating a substrate which is a belt, sheet, film, or tape, the method comprising the steps of preparing a pharmaceutical product by applying an active coating material to the substrate to form an active coating layer, the active coating material comprising biologically active material, wherein the active coating material is applied electrostatically as a powder, and, after the active coating material is applied, the active coating material is fused to form an active film layer, and wherein the active coating material is removable from the substrate as a wafer comprising the active film layer, and wherein the active coating layer is removed from the substrate as a wafer comprising the active film layer and divided into smaller portions.
A method of coating a substrate using a coating apparatus having a conveying surface, the method comprising the steps of preparing a pharmaceutical product by applying an active coating material to the substrate to form an active coating layer, said substrate being the conveying surface of the coating apparatus, the active coating material comprising biologically active material, wherein the active coating material is applied electrostatically as a powder, and, after the active coating material is applied, the active coating material is fused to form an active film layer, and wherein the active coating material is removable from the substrate as a wafer comprising the active film layer, and wherein the active coating is removed as a wafer comprising the active film layer and divided to provide individual dosages of the active material.
A method of coating a substrate which is a belt, sheet, film, or tape, the method comprising the steps of preparing a pharmaceutical product by applying an active coating material to the substrate to form an active coating layer, the active coating material comprising biologically active material, wherein the active coating material is removable from the substrate as a wafer comprising the active coating layer, and the active coating material is applied electrostatically as a powder, and wherein active coating material is applied to a plurality of individual regions on the substrate, wherein after the active coating layer is applied the active coating material is fused to form an active film coating and wherein the amount of active coating material deposited on a given area of the substrate is controlled such that the product can subsequently be divided into portions with each portion containing a pre-determined amount of active coating material, each predetermined amount being one dose of the active material.
A method of coating a plurality of coating regions onto the surface of a belt of a coating apparatus, the method comprising the steps of preparing a pharmaceutical product by:
- (a) applying an active coating material to the belt to form a plurality of active coating regions comprising active coating layers, the active coating material comprising biologically active material and being applied electrostatically as a powder wherein after the active coating material is applied the active coating material is fused to form regions of active film coating,
- (b) applying a cover coating material to a surface of the belt to form a plurality of cover coating regions, the cover coating regions forming layers of cover coating material, each active coating region being substantially completely covered by a cover coating region, wherein each region of active coating and cover coating is removable from the belt as a wafer comprising the active film coating and the cover coating, and wherein the active coating regions are removed as wafers each comprising the active film coating the cover coating and divided into portions.
A method of coating a belt of a coating apparatus, the method comprising the steps of preparing a pharmaceutical product by applying an active coating material to the belt to form an active coating layer, the active coating material comprising biologically active material, wherein the active coating material is applied electrostatically as a powder, and, after the active coating material is applied, the active coating material is fused to form an active film layer, and wherein the active coating material is removable from the belt as a wafer comprising the active film layer, and wherein the active coating is removed as a wafer comprising the active film layer and divided into smaller portions.
A method of coating a substrate using a coating apparatus having a conveying surface, the method comprising the steps of preparing a pharmaceutical product by
- applying a base coat layer to the substrate, said substrate being said conveying surface of the coating apparatus;
- applying an active coating material to the base coat layer to form an active coating layer, the active coating material comprising biologically active material;
- and
- applying a cover coating layer over the active coating layer, the three layers being removable together by peeling from the substrate in the form of a three-layer wafer, the base coat layer and the cover coating layer each being applied electrostatically as a powder and each being fused to form a film;
- removing the active coating layer as said three-layer wafer comprising the active coating layer;
- and
- dividing to form individual dosage units.
A method of coating a substrate using a coating apparatus having a conveying surface, the method comprising the steps of preparing a pharmaceutical product by:
- applying an active coating material to the substrate to form an active coating layer, said substrate being said conveying surface of the coating apparatus, the active coating material comprising biologically active material, wherein the active coating layer is removable from the substrate as a wafer comprising the active coating layer;
- supporting the substrate adjacent to a source of the active coating material with a surface of the substrate being maintained at such a different electric potential from that of the active coating material that the application of the electric potential causes the active coating material to move from the source of the active coating material towards the substrate, whereby a surface of the substrate becomes coated with the active coating material;
- and
- dividing to form individual dosage units.
A method of coating a substrate which is a belt, sheet, film, or tape, the method comprising the steps of preparing a pharmaceutical product by applying one or more coating layers to the substrate, the layer or the first layer being applied directly to a surface of the substrate, the layer or at least one of the layers comprising active coating material, the active coating material comprising biologically active material, wherein the active coating material is applied electrostatically as a powder and after the active coating material is applied the active coating material is fused to form an active film layer, and wherein the layer or layers applied are removable from the substrate as a coherent layer or layers and wherein the layer or layers applied are removed from the substrate as a wafer comprising the active film layer and divided into portions.
Dependencies are inferred from the claim text.