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US 6,783,539 B1Granted
Phototriggerable, collagen-crosslinking compounds for wound closure
AssigneeUniversity of Kansas Medical Center
InventorsGeorge T. Timberlake, Richard S. Givens, Peter G. Conrad, II
Life of this patent
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Abstract
A phototriggerable composition and method for use in crosslinking protein such as collagen comprising application of a tethered diazopyruvate composition followed by irradiation, whereby the composition results in the sutureless wound closure of, for example, a tendon or cornea.
Claims5
A method for crosslinking proteins comprising:
- (a) forming a hydrophilic, non-toxic photoactive composition;
- (b) applying said composition to a tissue with the tissue comprised of collagen, whereby the tissue wound is repaired;
- and,
- (c) irradiating such composition at a wavelength to form a reactive intermediate composition that forms covalent bonds with collagen protein, wherein the said intermediate is a ketoketene.
1 more element
Dependencies are inferred from the claim text.