Enzyme treatment
AssigneeChemgen Corporation
InventorsDavid M. Anderson, Lin Liu, Humg-Yu Hsiao, Douglas W. Fodge
Life of this patent
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Abstract
Enzymes of a particular class, characterized by the ability to cleave a linkage that effects release of a cell-surface protein or carbohydrate, which does not contain an anti-infection agent, display significant anti-infectious activity. Upon oral administration, these enzymes are effective, for example, in the treatment of digestive tract infections in humans and in animals. In the latter, there are benefits of significantly improved growth rate, feed efficiency, and overall health.
Claims39
A composition comprising (i) an enzyme that effects cleavage of a linkage that is comprised of a phosphatidylinositol and that membrane-anchors a surface protein or a carbohydrate on a pathogen, whereby said cleavage effects release of said surface protein or carbohydrate and (ii) a physiologically acceptable carrier for said enzyme, wherein said composition is in a form suitable for oral administration to a host and wherein said cleavage interferes with pathogen binding to a host cell in the intestines, such that the infective ability of said pathogen to said host cell is reduced.
Dependencies are inferred from the claim text.