Adjuvant for a vaccine composition
AssigneeAventis Pasteur Limited
InventorsJean Haensler, Emmanuelle Trannoy, Jorge Ronco
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Abstract
An amphipathic compound including a sterol-derived lipophilic grouping bound to a cationic grouping for use as an adjuvant in the delivery of a vaccine composition. In a particular embodiment, the lipophilic grouping is a cholesterol derivative and the cationic grouping is a quaternary ammonium or a protonatable amine. A vaccine composition including one or more antigens with at least one amphipathic compound having a sterol-derived lipophilic grouping bound to a cationic grouping, is also disclosed.
Claims25
A vaccine composition comprising at least one antigen and an adjuvanting amount of 3-β-(N-(N′-N-′-dimethylaminoethane)carbamoyl) cholesterol.
Dependencies are inferred from the claim text.