Back to results
US 6,780,327 B1Granted
Positively charged membrane
AssigneePall Corporation
InventorsXiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneePall Corporation
InventorsXiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
Estimating the term…
The present invention provides a positively charged microporous membrane having a protein binding capacity about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
A positively charged microporous membrane comprising a porous substrate and a crosslinked coating including a polymer backbone and pendant positively charged groups, wherein each pendant positively charged group is directly linked to the backbone through a polar spacer group by a single bond.
A positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a porous substrate and a crosslinked coating including polymer backbone and pendant positively charged groups, wherein each pendant positively charged group is directly linked to the backbone through a polar spacer group by a single bond.
A process for preparing a positively charged microporous membrane comprising a porous substrate and a diallylamine copolymer having pendant positively charged groups directly linked to the diallylamine copolymer through polar spacer groups, the process comprising:
A process for preparing a positively charged microporous membrane comprising a porous substrate and a diallylamine copolymer having pendant positively charged groups linked to the diallylamine copolymer through polar spacer groups, the process comprising:
A process for preparing a positively charged microporous membrane comprising a porous substrate and an acrylic polymer having pendant positively charged groups directly linked to the acrylic polymer through polar spacer groups, the process comprising:
A process for preparing a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising a polyalkyleneamine comprising pendant positively charged groups, wherein each pendant positively charged group is directly linked to the polyalkyleneamine through a polar spacer group by a single bond, the process comprising:
A positively charged microporous membrane having a nucleic acid binding capacity of about 5 mg/ml or more comprising a porous substrate and a crosslinked coating that includes a polymer backbone and pendant positively charged groups, wherein each pendant positively charged group is directly linked to the backbone through a polar spacer group by a single bond.
A positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising an acrylic copolymer having a backbone and pendant positively charged groups, wherein each positively charged group is attached to one atom of the backbone.
A positively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant positively charged groups comprising an acrylic copolymer, wherein the acrylic copolymer comprises a polymerized acrylic monomer selected from an acryloylaminoalkyl or acryloyloxyalkyl monomer.
A positively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant positively charged groups, wherein the crosslinking coating comprising a diallylamine copolymer, an acrylic monomer having a quaternary ammonium group, and a crosslinking agent, and wherein the crosslinking agent is an N-(alkoxymethyl)acrylamide.
A positively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant positively charged groups, wherein the crosslinked coating includes comprising a diallylamine copolymer, an acrylic monomer having a quaternary ammonium group, and a crosslinking agent, and wherein the acrylic monomer is an acryloylaminoalkyl or acryloyloxyalkyl trialkylammonium halide.
A positively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant positively charged groups, wherein the crosslinked coating includes an acrylic copolymer comprising a polymerized monomer selected from the group consisting of glycidylalkylacrylate, methacryloyloxyalkyl trialkylammonium halide, and methacryloylaminoalkyl trialkylammonium halide.
A positively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant positively charged groups, wherein the crosslinked coating includes an acrylic copolymer linked to pentaethylenehexamine.
Dependencies are inferred from the claim text.