Fullerene pharmaceutical compositions for preventing or treating disorders
AssigneeNational Health Research Institute
InventorsHuan-Yao Lei, Chen-Kung Chou, Tien-Yau Luh
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Abstract
The present invention relates to a method for treating a disease, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a fullerene. The diseases treated comprise bacterial and viral diseases such as those cause by Gram positive and Gram negative bacteria, Dengue 2 virus and viral encephalitis. The fullerene is administered in vivo in an amount of about 0.001 to about 100 mg/kg of body weight of the subject.
Claims23
A method for treating a disease, comprising administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising a compound of Formula II:
- F(N—Z)m (II)
- wherein
- N is attached to two vicinal carbon atoms of a fullerene skeleton at a [6,6] ring junction and form a fused aziridine ring;
- F is a fullerene core;
- Z is selected from the group consisting of —CO2H, —SO3H and —PO3H;
- and
- m is 1—10;
- or a pharmaceutically acceptable salt thereof.
A method for treating a bacterial or viral disease comprising administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising a compound of Formula I:
- F [C—X(Y)n]m (I)
- wherein
- C is attached to two vicinal carbon atoms of a fullerene skeleton at a [6,6] ring junction and form a fused cyclopropane ring;
- F is a fullerene core;
- X and Y are identical or different, and are independently selected from the group consisting of —CO2H, —SO3H and —PO3H;
- n is 0 or 1;
- and
- m is 1-10;
- or a pharmaceutically acceptable salt thereof.
A method for inhibiting cytokine production, comprising administering to a subject a pharmaceutically effective amount of a pharmaceutical composition comprising a fullerene.
A method for enhancing neutrophil infiltration to treat a disease, comprising administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising a fullerene.
Dependencies are inferred from the claim text.