Isoquinoline compounds having antiinfective activity

A compound of the formula

• and the pharmaceutically acceptable salts thereof,
• wherein
• m is an integer from 1 to 25, inclusive;
• each moiety —(NH—Y—CO)— is independently selected from the group consisting of
• (a) moieties M1 of the formula
• wherein one of X1, X2, and X3 is a ring vertex selected from the group consisting of —O—, —S—, and —NR2—, and the other two of X1, X2, and X3 are ring vertices selected from the group consisting of ═N— and ═CR1—;
• (b) moieties M2 of the formula
• wherein x is 0 or 1 and each R15 is independently H, OH, NH2, or F;
• (c) moieties M3 of the formula
• wherein each L is independently a divalent moiety separating —NH— and —(C═O)— by 3 or 4 atoms;
• and
• (d) moieties M4 of the formula
• wherein at least one moiety —(NH—Y—CO)— is M1;
• Z is O or N;
• n is 1 if Z is O and 2 if Z is N;
• each R1 is independently H, F, Cl, Br, I, CN, OH, NO2, NH2, a substituted or unsubstituted (C1-C12)alkyl group, a substituted or unsubstituted (C1-C12)alkoxy group, or a substituted or unsubstituted (C1-C12)heteroalkyl group;
• and
• each R2 is independently H, a substituted or unsubstituted (C1-C12)alkyl group, or a substituted or unsubstituted (C1-C12)heteroalkyl group;
• the compound having a basic group having a pKb of 12 or less or a quaternized nitrogen group.