Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
AssigneeBoehringer Ingelheim Pharma GmbH & Co. KG
InventorsRolf Banholzer, Peter Sieger, Christian Kulinna, Michael Trunk, Manfred Graulich, Peter Specht, Helmut Meissner, Andreas Mathes
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Abstract
Crystalline monohydrate of (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof, and their use.
Claims16
Crystalline tiotropium bromide monohydrate having an endothermic peak at 230° C.±5° C. occurring during thermal analysis using DSC at a heating rate of 10 K/min.
Crystalline tiotropium bromide monohydrate having an IR spectrum comprising bands at wave numbers 3570, 3410, 3105, 1730, 1260, 1035, and 720 cm−1.
Dependencies are inferred from the claim text.