Method for producing optically active mandelic acid derivatives
AssigneeDaicel Chemical Industries, Ltd.
InventorsKazuya Mitsuhashi, Hiroaki Yamamoto
Life of this patent
Estimating the term…
Abstract
The present invention provides a method for enzymatically producing optically active mandelic acid derivatives. An optically active mandelic acid derivative (shown as Formula II) is produced by reacting a culture or cell body of a microorganism, or processed products thereof, with a phenylglyoxylic acid derivative, and then recovering the obtained optically active mandelic acid derivative, wherein the microorganism has the ability to stereo-selectively reduce the phenylglyoxylic acid derivative. An optically active mandelic acid obtained according to the present invention is useful as an intermediate for the synthesis of pharmaceuticals and agricultural chemicals.
Claims9
A method for producing an optically active mandelic acid derivative, which comprises the steps of:
- (a) reacting a culture or cell bodies of a microorganism, or processed products thereof that can steroselectively reduce a phenylglyoxylic acid derivative of the formula (I) with said phenylglyoxylic acid derivative of the formula (I):
- wherein:
- X is hydrogen, alkali metal, or alkaline earth metal;
- R indicates one or more substituents at ortho, meta, or para position, wherein the substituent is halogen, hydroxyl group, alkyl group having 1 to 3 carbon atoms, alkoxy group, thioalkyl group, amino group, nitro group, mercapto group, phenyl group, or phenoxy group;
- (b) stereo-specifically reducing said phenylglyoxylic acid derivative with said microorganism culture, cell bodies or processed products to yield an optically active mandelic acid derivative of the formula (II):
- wherein:
- X and R is defined for formula (I);
- and
- (c) recovering said optically active mandelic acid derivative.
Dependencies are inferred from the claim text.