Histone deacetylases, and uses related thereto
AssigneePresident and Fellows of Harvard College
InventorsStuart L. Schreiber, Jack Taunton, Christian A. Hassig, Timothy F. Jamison
Life of this patent
Estimating the term…
Abstract
The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
Claims11
An isolated nucleic acid encoding a histone deacetylase gene family (HDx) polypeptide having a histone deacetylase activity, which HDx polypeptide comprises a ν motif represented in the general formula
- DIAX1NWAGGLHHAKKX2EASGFCYVNDIVX3X4ILELLKYHX5RVLYLDIDIHHGDGX6EA FYX7TDRVMTVSF (SEQ ID NO:
- 13) and a χ motif represented in CVEX1VKX2FNX3P-X4LX5LGGGGYTX6RNVARCWTYET (SEQ ID NO:
- 16), and which nucleic acid hybridizes under stringent conditions of 6.0×SSC at 65° C. to the nucleotide sequence designated in SEQ ID NO:
- 1.
An isolated nucleic acid encoding an HDx polypeptide sequence or fragment thereof, which can deacetylate an acetylated histone substrate, and which polypeptide comprises the polypeptide sequence designated in SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.