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US 6,777,179 B2Granted
Method for selective inactivation of viral replication
AssigneeRigel Pharmaceuticals, Inc.
InventorsVincent J. Miles, Michael B. Mathews, Michael G. Katze, Julia C. Watson, Gary Witherell
Life of this patent
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Abstract
Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA compared to a host RNA under virus infection conditions; and determining whether any interaction of the agent with the component reduces the level of translation of an RNA of the virus.
Claims15
A method for screening for a potential antiviral agent, comprising the steps of:
- a) determining whether an agent interacts with a viral or cellular component, wherein said component allows or prevents translation of a virus RNA under virus infection conditions;
- and
- b) determining whether any interaction of said agent with said component reduces the level of translation of a RNA of said virus
- wherein an agent that reduces said level of translation is a potential antiviral agent.
1 more element
A method for screening for a potential antiviral agent, comprising:
- determining whether an agent reduces the level of translation of a RNA of a virus through interaction with a viral or cellular component that, under virus infection conditions, allows or prevents translation of a virus RNA,
- wherein an agent that reduces said level of translation is a potential antiviral agent.
Dependencies are inferred from the claim text.