Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
AssigneeIowa State University Research Foundation, Inc.
InventorsPrem S. Paul, Yanjin Zhang
Life of this patent
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Abstract
The present invention provides an isolated DNA sequence encoding, for example, at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), specifically ISU-55, and the polypeptides encoded by the isolated DNA sequences. The present invention also concerns a vaccine comprising an effective amount of such a protein; methods of producing antibodies which specifically bind to such a protein; and methods of protecting a pig against a PRRSV, and treating a pig infected by a PRRSV.
Claims27
An isolated DNA sequence encoding a porcine reproductive and respiratory syndrome virus (PRRSV) consisting of SEQ ID NO:54 (ISU-55).
An isolated DNA sequence comprising nucleotides 191-7699 of SEQ ID NO:54 (ORF 1a), nucleotides 7687-12069 of SEQ ID NO:54 (ORF 1b), nucleotides 12074-12841 of SEQ ID NO:54 (ORF 2), nucleotides 12692-13458 of SEQ ID NO:54 (ORF 3), nucleotides 13212-13775 of SEQ ID NO:54 (ORF 4), nucleotides 13789-14388 of SEQ ID NO:54 (ORF 5), nucleotides 14376-14592 of SEQ ID NO:54 (ORF 6)) or nucleotides 14890-15258 of SEQ ID NO:54 (ORF 7).
A composition for inducing antibodies against PRRSV comprising a PRRSV encoded by SEQ ID NO:54 (ISU-55), and a physiologically acceptable carrier.
An isolated DNA sequence comprising nucleotides 12692-13458 of SEQ ID NO:54 (ORF 3), nucleotides 13212-13775 of SEQ ID NO:54 (ORF 4), or nucleotides 13789-14388 of SEQ ID NO:54 (ORF 5).
An isolated DNA sequence comprising nucleotides 14376-14592 of SEQ ID NO:54 (ORF 6) or nucleotides 14890-15258 of SEQ ID NO:54 (ORF 7).
An isolated DNA sequence comprising nucleotides 12074-12841 of SEQ ID NO:54 (ORF 2).
Dependencies are inferred from the claim text.