Magnetically-responsive microspheres
AssigneeLuminex Corporation
InventorsDon J. Chandler, Michael A. Herren
Life of this patent
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Abstract
Microspheres are constructed using magnetic particles. Hybrid microspheres are constructed using fluorescent or luminescent microspheres and magnetic nanoparticles. Reactive moieties on the surface of the resultant particles can be used for attachment of biologically active molecules, thus allowing selective separations and analytical assays to be performed. Distinguishable subsets of microspheres can be constructed based on fluorescent intensities, and separations can be affected based on variable degree of magnetic content.
Claims28
A particle, comprising:
- a core particle;
- and
- at least one substance, bonded covalently with said core particle, comprising magnetic material and polymeric material, wherein an amount and type of magnetic material in said substance ranges from greater than 0% to nearly 100% of said substance, and wherein said amount and type of magnetic material is chosen to achieve a desired magnetic response from said particle upon exposure to a magnetic field.
A particle, comprising:
- a core particle;
- and
- an amount of at least one magnetic substance, bonded covalently with said core particle, wherein said amount of said at least one magnetic substance is effective to achieve a desired magnetic response from said particle upon exposure to a magnetic field.
A set of particles, comprising:
- pooled populations of particles comprising at least a first population of particles and another population of particles, wherein particles of each population comprise at least one magnetic substance covalently bonded with a core particle in an amount effective for achieving a desired magnetic response upon exposure to a magnetic field, and wherein said first population of particles is distinguishable from said another population of particles based at least on said desired magnetic response of the particles within said first population upon exposure to a magnetic field.
A method of forming magnetically-responsive particles, comprising:
- bonding covalently with a core particle at least one magnetic substance in an amount effective for achieving a desired magnetic response upon exposure to a magnetic field.
A method of forming a magnetically-responsive population of particles, comprising:
- selecting an amount of magnetic substance for achieving a desired magnetic response upon exposure to a magnetic field;
- selecting a population of particles wherein particles of said population comprise core particles;
- and
- covalently bonding the amount of magnetic substance with said core particles.
A method of forming a pooled set of magnetically-responsive populations of particles, said particles comprising a core particle and at least one magnetic substance bonded covalently with said core particle, comprising:
- combining a population of particles having a desired magnetic response with at least one other population of particles having a different desired magnetic response.
Dependencies are inferred from the claim text.