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US 6,770,729 B2Granted
Polymer compositions containing bioactive agents and methods for their use
AssigneeMedtronic MiniMed, Inc.
InventorWilliam P. Van Antwerp
Life of this patent
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Abstract
Embodiments of the invention provide polymer coated implantable medical devices having a bioactive material posited in or on at least a portion of the coating layer, wherein the coating layer provides for the controlled release of the bioactive material from the coating layer. Preferably, the medical device is an intravascular stent.
Claims18
An implantable medical device having at least one polymer coating composition, the polymer coating prepared from a reaction mixture of:
- (a) a diisocyanate, the diisocyanate comprising about 50 mol % of the reactants in the mixture;
- (b) a hydrophilic polymer which is a member selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof;
- (c) a bioactive agent, wherein the bioactive agent is an anti-thrombocytic, anti-inflammatory or anti-proliferative agent;
- and optionally;
- (d) a chain extender.
2 more elements
An implantable medical device having at least one polymer coating composition, the polymer coating prepared from a reaction mixture of:
- (a) a diisocyanate, the diisocyanate comprising about 50 mol % of the reactants in the mixture;
- (b) a hydrophilic polymer which is a member selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof;
- (d) glucose oxidase;
- (c) a bioactive agent wherein the bioactive agent is capable of being released from the polymer coating into the environment in which the medical device is placed, and wherein the bioactive agent is an anti-thrombocytic, anti-inflammatory or anti-proliferative agent;
- wherein the release of the bioactive agent is modulated by a product that is produced from a reaction between the glucose oxidase that is present in the polymer coating and glucose that is present environment in which the medical device is placed.
2 more elements
Dependencies are inferred from the claim text.