US 6,770,639 B2 · Heterocyclic compounds useful as inhibitors of tyrosine kinases

Abstract

Disclosed are novel compounds of formula (I): wherein Ar1, Ra, R4, R5, X and Y are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases associated with such kinases, for example, diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are processes for preparing these compounds, novel intermediates useful in these processes and compositions comprising compounds of the formula (I).

A Compound of the formula(I):

wherein:
Ar1 is an aromatic or nonaromatic carbocycle, heteroaryl selected from pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrrolyl, imidazolyl, pyrazolyl, thienyl, furyl, isoxazolyl, isotbiazolyl, oxazolyl, oxadiazolyl, thiazolyl, thiadiazolyl, quinolinyl, isoquinolinyl, indolyl, benzimidazolyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, benzpyrazolyl, benzothiofuranyl, beuzothiazolyl, quinazolinyl, and indazolyl, or a fused heteroaryl selected from cyclopentenopyridine, cyclohexanopyridine, cyclopentanopyrimidine, cyclohexanopyrimidine, cyclopentanopyrazine, cyclohexanopyrazine, cyclopentanopyridazifle, cyclohexanopyridazine, cyclopentanoquinoline, cyclohexanoquinoline, cyclopentanoisoquinolifle, cyctohexanoisoquinoline, cyclopentanoindole, cyclohexanoindole, cyclopentanobenzimidazole, cyclohexanobenzimidazole, cyclopentanobenzoxazole, cyclohexanobeuzoxazole, cyclopentanoimidazole, cyclohexanoimidazole, cyclopentanothiophene and cyclohexanothiophene;
or
a heterocycle selected from pyrrolinyl, pyrrolidinyl, pyrazolinyl, pyrazolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, pyranyl, thiopyranyl, piperazinyl and indolinyl;
wherein said carbocycle, heteroaryl or heterocycle is optionally substituted by one or more R1, R2 and R3;
X is NH, N—C1-3alkyl, N-cyclopropyl;
Y is NR15, S or O;
Ra is H, C1-10alkyl, C2-10alkenyl or C2-10alkynyl, each of which may be branched or cyclic;
or
Ra is aryl or heteroaryl;
wherein each Ra is independently optionally substituted with one or more C1-6alkyl, C1-6 alkoxy, halogen. OH, oxo, NR10R11, aryl or heteroaryl each aryl or heteroaryl being optionally substituted with one or more groups selected from halogen, OH, C1-3alkyl, C1-3alkoxy, hydroxyC1-3alkyl and (CH2)mNR10R11;
and wherein Ra is attached at the 4- or 5- position;
R1 and R2 are the same or different and selected from H, halogen, CN, NO2, C1-10 branched or unbranched saturated or unsaturated alkyl, C1-10 branched or unbranched alkoxy, C1-10 branched or unbranched acyl, C1-10 branched or unbranched acyloxy, C1-10 branched or unbranched alkylthio, aminosulfonyl, di(C1-3)alkylaminosulfonyl, NR10R11, aryl, aroyl, aryloxy, arylsulfonyl, heteroaryl and heteroaryloxy;
wherein the abovementioned R1 and R2 are optionally partially or fully halogenated or optionally substituted with one to three groups independently selected from oxo, OH, NR10R11, C1-6 branched or unbranched alkyl, C3-7cycloalkyl, phenyl, naphthyl, heteroaryl, aminocarbonyl and mono- or di(C1-3)alkylaminocarbonyl;
R3 is H, halogen, OH, (CH2)nNR10R11, CONR10R11, (CH2)nCO2R12;
C1-3alkyl optionally substituted with OH, C1-3 alkoxy optionally halogenated or C1-3 alkylthio;
R4 and R5 together with the atoms to which they are attached complete a fused ring system of the formulas A or B:
R6 is C1-3alkyl or H;
R7 is C1-6alkyl branched or unbranched or H;
R8 is H, C1-6alkyl branched or unbranched, saturated or unsaturated, optionally substituted with phenyl, OH or C1-3alkoxy;
or R8 is (CH2)mNR10R11, (CH2)mNR10COR12, (CH2)nCO2R12, (CH2)nCONR10R11;
or R8 is phenyl or heteroaryl, each being optionally substituted with C1-3alkyl, C1-3alkoxy, OH, —SO3H or halogen;
R9 is H, CN or CONR10R11;
or R9 is C1-10alkyl branched or unbranched, C3-10cycloalkyl, C5cycloalkenyl, C2-6 alkenyl, C2-6 alkynyl each being optionally substituted with one or more C3-10cycloalkyl, C3-10cycloalkylidene, C5-7cycloalkenyl, halogen, OH, oxo, CN, C1-3alkoxy, C1-3acyloxy, NR10R11, NR10CONR10R11, NR10C(═NR10)NR10R11, NR10COR12, NR10S(O)pR12, SR12, CONR10R11, CO2R12, C(R10)═NNR10R11, C(R10)═NNR10CONR10R11, aryloxy, arylthio, aryl or heteroaryl;
wherein each aryloxy, arylthio, aryl or heteroaryl is optionally substituted with C1-3alkyl, C1-3alkoxy, halogen, (CH2)nNR10R11 or O(CH2)2-4NR10R11;
or R9 is aryl, heteroaryl, or heterocycle, wherein each aryl, heteroaryl or heterocycle is optionally substituted with one to three groups selected from C1-3alkyl optionally substituted with phenyl or NR10C(═NR10)NR10R11, C1-3alkoxy, halogen, CN, oxo, (CH2)nNR10R11, (CH2)nCO2R12;
(CH2)nCONR10R11 and O(CH2)2-4NR10R11;
or R8 and R9 together form a saturated or unsaturated 5 or 6 membered aromatic or nonaromatic carbocyclic ring optionally substituted by one or two C1-3alkyl, OH, oxo or (CH2)nNR10R11, or optionally spiro-fused to a 1,3 dioxolane group or 1,3 dithiolane group, each 1,3 dioxolane group or 1,3 dithiolane group optionally substituted by C1-6alkyl, C1-6alkoxy, OH or (CH2)nNR10R11;
R10 and R11 may be the same or different and are each independently selected from H, OH, C1-3alkoxy, C1-6alkyl branched or unbranched, C3-8cycloalkyl, aryl, arylC1-3alkyl and heteroaryl;
wherein said alkyl, cycloalkyl, aryl, arylC1-3alkyl or heteroaryl are optionally substituted with OH, C1-3alkoxy, CN, NO2, C1-3acyloxy, CO2R12, NR13R14, O(CH2)2-4NR13R14, aryl or heteroaryl;
or R10 and R11 together form a 3-7 member alkylene chain completing a ring about the N atom to which they are attached;
wherein said alkylene chain is optionally interrupted by O, S(O)p, and NR13;
and wherein said ring is optionally substituted by C1-3 alkyl, C1-3alkoxy, OH, —(CH2)nNR13R14, CONR13R14 or NR13COR14;
R12 is H, C1-6alkyl or C3-8cycloalkyl wherein each alkyl or cycloalkyl is optionally substituted with phenyl, OH, C1-3alkoxy or NR13R14;
or R12 is phenyl or heterocycle, optionally substituted with one to three groups selected from C1-3alkyl, C1-3alkoxy, halogen, (CH2)mNR10R11, (CH2)nCONR10R11 and O(CH2)2-4NR10R11;
R13 and R14 are each independently selected from H and C1-6 alkyl optionally substituted with C1-3alkoxy, OH or phenyl;
or R13 and R14 together form a chain completing a ring, said chain is (CH2)4-5 or (CH2)2O(CH2)2;
R15 is H or C1-3 alkyl;
m is 1-4;
n is 0-3 and p is 0-2;
or
a pharmaceutically acceptable ester or salt thereof;
with the proviso that at least one or more of Ra, Ar1, R8 and R9 are or contain a heterocycle or heteroaryl.

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Heterocyclic compounds useful as inhibitors of tyrosine kinases

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Heterocyclic compounds useful as inhibitors of tyrosine kinases

Life of this patent

Abstract

Claims21