Live attenuated RTX-producing bacteria of the family pasteurellaceae
AssigneeAkzo Nobel N.V.
InventorsRuud Philip Antoon Maria Segers, Johannes Franciscus Van Den Bosch, Joachim Frey
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Abstract
The present invention relates to live attenuated RTX-toxin producing bacteria of the family Pasteurellaceae, of which the attenuation is due to the fact that they produce RTX toxin in a non-activated form. The invention also relates to vaccines for the protection of mammals against infection with RTX-toxin producing bacteria of the family Pasteurellaceae, and to methods for the preparation of said live attenuated bacteria and vaccines.
Claims7
An isolated live, attenuated Apx toxin-producing Actinobacillus pleuropneumoniae having a deletion in two apx activator genes wherein said Actinobacillus pleuropneumoniae does not produce two functional Apx activator proteins, but produces two Apx toxins in a non-activated form.
A method for producing an isolated live, attenuated RTX toxin-producing Actinobacillus pleuropneumoniae that produces two Apx toxins in a non-activated form, said method comprising introducing a deletion in two apx activator genes whereby said Actinobacillus pleuropneumoniae does not produce two functional Apx activator proteins, but produces said two Apx toxins in a non-activated form.
Dependencies are inferred from the claim text.