Neo-tryptophan
AssigneeMayo Foundation for Medical Education and Research
InventorsElliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq
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Abstract
The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.
Claims2
A method of synthesizing neo-tryptophan, said method comprising:
- a) providing 4-hydroxymethyl indole, and
- b) substituting the hydroxyl group of said 4-hydroxymethyl indole with a glycyl unit to produce neo-tryptophan.
Dependencies are inferred from the claim text.