Immunological detection of prions
AssigneeUniversitäT ZüRich
InventorsCarsten Korth, Beat Stierli, Peter Stregt, Bruno Oesch, Markus Moser
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Abstract
The presented invention relates to monoclonal antibodies useful in sensitive and specific immunological assays for the identification of prions in various tissues and body fluids, the production of such monoclonal antibodies by means of immunization of PrP0/0 mice by means of a new recombinant fragment of PrP and the use of the antibodies, e.g. for therapeutic and preventive treatments of humans and animals suffering from prion diseases.
Claims15
An isolated monoclonal antibody or a fragment thereof, wherein said antibody and said fragment are capable of binding only to native disease-specific prion protein (PrPSc) and not to native normal prion protein PrPC) in an antigen-antibody complex.
Dependencies are inferred from the claim text.