Compositions and methods for enhancing corticosteroid delivery
AssigneeMedicis Pharmaceutical Corporation
InventorsEugene H. Gans, Mitchell S. Wortzman
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Abstract
The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.
Claims17
A composition comprising
- One or more corticosteroids, wherein one corticosteroid comprises fluocinonide;
- Two or more penetration enhancers selected from the group consisting of diisopropyl adipate, dimethyl isosorbide, propylene glycol, 1,2,6-hexapetriol, and benzyl alcohol;
- and
- one or more of the group consisting of solvents and emulsifiers, wherein the penetration enhancers are present in a ratio to a total of the penetration enhancers, and solvents and emulsifiers of at least about 0.90.
A composition comprising about 0.10% fluocinonide, about 74.9% propylene glycol, about 3.0% diisopropyl adipate, about 5.0% isopropyl myristate, about 2.5% 1,2,6 trihydroxyhexane, about 1.0% carbopol 980, about 1.0% diisopropanolamine 85%:
- propylene glycol (1:9), about 0.01% citric acid, about 2.49% purified water, about 2.5% glyceryl monostearate, and about 7.5% glyceryl monostearate & PEG stearate.
A composition comprising about 0.10% fluocinonide, about 70.0% propylene glycol, about 15.0% dimethyl isosorbide, about 1.2% carbopol 980, about 1.2% diisopropanolamine 85%:
- propylene glycol (1:9), about 0.01% citric acid, about 2.49% purified water, about 2.5% glyceryl monostearate, and about 7.5% glyceryl monostearate & PEG stearate.
A composition comprising about 0.10% fluocinonide, about 66.8% propylene glycol, about 5.0% dimethyl isosorbide, about 5.0% isopropyl myristate, about 0.5% carbopol 980, about 0.5% diisopropanolamine 85%:
- propylene glycol (1:9), about 5.0% white petrolatum USP, about 60% glyceryl monostearate, about 6.0% PEG 100 stearate, about 5.0% stearyl alcohol, and about 0.10% sodium lauryl sulfate.
A composition comprising about 0.10% fluocinonide, about 69.9% propylene glycol, about 2.0% diisopropyl adipate, about 5.0% isopropyl myristate, about 0.5% carbopol 980, about 0.5% diisopropanolamine 85%:
- propylene glycol (1:9), about 5.0% white petrolatum USP, about 6.0% glyceryl monostearate, about 6.0% PEG 100 stearate, and about 5.0% stearyl alcohol.
Dependencies are inferred from the claim text.