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US 6,764,831 B2Granted
Methods and compositions for pain management
AssigneesProteome Sciences plc, Bruce M. Cameron, Sr.
InventorsBruce M. Cameron, Sr., Robert C. Allen
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AssigneesProteome Sciences plc, Bruce M. Cameron, Sr.
InventorsBruce M. Cameron, Sr., Robert C. Allen
Estimating the term…
The present invention provides novel methods and diagnostic kits for the objective measurement of the severity of pain or stress being experienced by a patient with a disorder, diagnosis and treatment for patients suffering from painful disorders, and monitoring the effectiveness of different pain-treatment protocols. Pain-measuring methods comprise collecting a sample from a patient and determining the presence of a pain-associated marker in the sample. Methods for alleviating pain comprise administrating a dose of a therapeutically effective amount of a composition to the patient wherein the dose is determined by the presence of a pain-associated marker in a biological sample obtained from the patient. Compositions for alleviating pain comprise substances that are pain-associated markers or agents that interfere with pain-associated markers, and block or modulate the progression of pain perceived by the patient.
A method for identifying a marker that correlates with the intensity of a pain perceived by a patient comprising the steps of:
A method of diagnosing the extent of activation of the pain sensing neurological pathway in a patient comprising:
A diagnostic kit for determining the level of activation of the pain sensing neurological pathway in a patient comprising at least one antibody that binds to cholinesterase in a biological sample obtained from the patient wherein the amount of cholinesterase in the sample is then compared with an amount of cholinesterase known to be indicative of activation of the pain sensing neurological pathway.
A method of diagnosing the extent of activation of the pain sensing neurological pathway in a patient comprising:
A method for determining the efficacy of a treatment for pain comprising:
A diagnostic kit for determining the level of activation of the pain sensing neurological pathway in a patient comprising at least one agent that reacts with cholinesterase in a biological sample obtained from a patient wherein the amount of cholinesterase in the sample is then compared with an amount of cholinesterase known to be indicative of activation of the pain sensing neurological pathway.
A method of diagnosing the extent of activation of the pain sensing neurological pathway in a patient comprising:
Dependencies are inferred from the claim text.