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US 6,762,406 B2Granted
Ion trap array mass spectrometer
AssigneePurdue Research Foundation
InventorsRobert G. Cooks, Ethan R. Badman, Zheng Ouyang, James M. Wells
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Abstract
A mass spectrometer having an array of parallel and/or tandem ion traps. The ion traps are preferably formed by providing a body of conductive material with a plurality of holes forming ring electrodes and electrodes on opposite faces of said body, opposite the ends of said ring electrodes, to define with the ring electrodes a plurality of parallel ion traps.
Claims49
An ion trap mass spectrometer comprising:
- a body soley of conductive material having first and second major surfaces,
- a plurality of parallel holes extending through said body from the first major surface to the second major surface each forming the ring electrodes of individual ion trap,
- a first electrode spaced from said first major surface of said body,
- a second electrode spaced from said second major surface of said body,
- said first and second electrodes forming an endcap for each of said ring electrodes to define a plurality of parallel ion traps and;
- means for applying selectively rf and/or dc voltages between said end electrodes and said body to selectively trap and/or eject ions.
3 more elements
An ion trap mass spectrometer comprising:
- a disc-shaped body of conductive material having first and second major surfaces with at least one of said surfaces shaped such that said body has annular regions of different thickness,
- a plurality of holes extending through said body from the first major surface to the second major surface, each forming the ring electrode of an individual ion trap, said holes extending through the thinner annular regions having a smaller diameter than the holes extending through the thicker annular regions,
- a first electrode shaped to conform to the shape of the first major surface of said body,
- a second electrode shaped to conform to the shape of the second major surface of said body,
- said first and second electrodes forming an endcap for each of said ring electrodes to define therewith a plurality of parallel ion traps.
2 more elements
An ion trap mass spectrometer comprising:
- a body soley of conductive material having first and second major surfaces,
- a plurality of parallel holes extending through said body from the first major surface to the second major surface, each forming the ring electrode of an ion trap,
- a first electrode spaced from said first major surface of said body,
- a second electrode spaced from said second major surface of said body,
- said first and second electrodes forming an endcap for each of said ring electrodes to define a plurality of parallel ion traps,
- means for forming ions in said ion traps or for injecting ions into said ion traps, and
- means for selectively applying dc and/or rf voltage between said conductive body and electrodes to trap ions of predetermined mass-to-charge ratio in each of said ion traps.
4 more elements
An ion trap mass spectrometer comprising a first parallel array of ion traps including:
- a body of conductive material having first and second major surfaces,
- a plurality of parallel holes extending through said body from the first major surface to the second major surface, each forming the ring electrodes of ion traps,
- a first electrode spaced from said first major surface of said body,
- a second electrode spaced from said second major surface of said body,
- said first and second electrodes forming an endcap for each of said ring electrodes to define said first parallel array of ion traps, and
- a second parallel array of ion traps including:
- a body of conductive material having first and second major surfaces,
- a plurality of parallel holes extending through said body from the first major surface to the second major surface, each forming the ring electrodes of individual ion traps,
- a first electrode spaced from said first major surface of said body,
- a second electrode spaced from said second major surface of said body,
- said first and second electrodes forming an endcap for each of said ring electrodes to define said second parallel array of ion traps,
- said first parallel array of ion traps positioned so that the second electrodes of said first parallel array of ion traps faces the first electrode of said second parallel array of ion traps to form a tandem mass spectrometer.
9 more elements
An ion trap mass spectrometer comprising a plurality of ion traps each including
- a ring electrode and end cap electrodes,
- means for applying the same rf/dc trapping voltages between said ring electrodes and said end caps whereby to trap ions of mass-to-charge ratio determined by the r0/z0 dimensions of each of said ion traps.
An ion trap mass spectrometer comprising a plurality of substantially cylindrical ion traps placed in parallel next to each other.
An ion trap mass spectrometer comprising a plurality of ion traps each including a cylindrical electrode defining a trapping region and end cap electrodes at each end of said cylindrical electrode arranged in parallel to receive sample ions and simultaneously perform a mass analysis.
A mass spectrometry instrument comprising:
- a sample inlet;
- an ion source configured to receive a sample from the sample inlet;
- a quadrupole ion trap, the quadrupole ion trap comprising;
- a disk shaped body consisting of conductive material having first and second major surfaces with at least one of said surfaces shaped such that said body has thinner annular regions and thicker annular regions;
- a plurality of parallel holes extending through said body from the first major surface to the second major surface each forming the ring electrodes of an individual ion trap, said holes extending through the thinner annular regions having a smaller diameter then the holes extending through the thicker annular regions;
- a first electrode spaced from said first major surface of said body and shaped to conform to the shape of the first major surface of said body;
- a second electrode spaced from said second major surface of said body and shaped to conform to the shape of the second major surface of said body, said first and second electrodes forming an end cap for each of said ring electrodes to define a plurality of parallel ion traps;
- circuitry for selectively applying dc and rf voltage between said conductive body and electrodes to trap a plurality of ions in each of said ion traps, said plurality of ions having a plurality of m/z ratios;
- and
- an ion detector configured to detect ions having a plurality of mass-to-charge rations.
7 more elements
A mass spectrometry analytical method comprising:
- ionizing a sample to create at least one ion;
- focusing the at least one ion into a quadrupole ion trap, the quadrupole ion trap comprising:
- a disk shaped body consisting of conductive material having first and second major surfaces with at least one of said surfaces shaped such that said body comprises first annular regions and second annular regions, the first annular regions being thicker than the second annular regions;
- a plurality of parallel holes extending through said body from the first major surface to the second major surface each forming the ring electrodes of an individual ion trap, said holes extending through the first annular regions having a smaller diameter than the holes extending through the second annular regions;
- a first electrode spaced from said first major surface of said body and shaped to conform to the shape of the first major surface of said body;
- and
- a second electrode spaced from said second major surface of said body and shaped to conform to the shape of the second major surface of said body, said first and second electrodes forming an endcap for each of said ring electrodes to define a plurality of parallel ion traps;
- applying a first predetermined rf and dc voltage between the body and endcaps respectively to trap the at least one ion;
- increasing the amplitude of the rf voltage according to a predetermined rate to eject the at least one ion;
- and
- detecting the ejected ion.
8 more elements
Dependencies are inferred from the claim text.