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US 6,762,283 B1Granted
Caspase-8 interacting proteins
AssigneeYeda Research and Development Co. Ltd.
InventorsDavid Wallach, Marcus Schuchmann, Tanya Goncharov
Life of this patent
Estimating the term…
Abstract
There are provided proteins which interact with caspase-8. Production and use of such proteins is also provided.
Claims7
A purified polypeptide that binds to caspase-8, said polypeptide comprising:
- (a) the amino acid sequence of SEQ ID NO:6;
- (b) the amino acid sequence of an analog of (a), having no more than ten changes in the amino acid sequence of (a), each said change being a substitution, deletion or insertion of an amino acid, which analog binds to caspase-8;
- (c) the amino acid sequence of a polypeptide encoded by a DNA sequence capable of hybridizing with the DNA sequence of SEQ ID NO:5, under moderately stringent conditions, which polypeptide binds to caspase-8;
- (d) a derivative of (a), (b), or (c), which binds to caspase-8.
1 more element
A purified polypeptide that binds to caspase-8, said polypeptide consisting of the amino acid sequence of a fragment of SEQ ID NO:
- 6, which fragment binds to caspase-8, or a derivative thereof which binds to caspase-8.
Dependencies are inferred from the claim text.