BTK inhibitors and methods for their identification and use
AssigneeParker Hughes Institute
InventorsFatih M. Uckun, Ravi Malaviya
Life of this patent
Estimating the term…
Abstract
The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors, including allergy treatments.
Claims32
A method to alter leukotriene production from mast cells, the method comprising contacting mast cells with an effective leukotriene-altering amount of a LFM analogue of the formula:
- where X is H, Br, Cl, F, CF3, or OCF3;
- or a pharmaceutically acceptable salt thereof.
A method for treating or preventing asthma in a mammal, the method comprising administering to a mammal a therapeutically effective amount of a LFM analogue of the formula:
- where X is H, Br, Cl, F, CF3, or OCF3;
- or a pharmaceutically acceptable salt thereof.
A method of altering the number of eosinophils in bronchioles, the method comprising administering to a mammal a therapeutically effective amount of a LFM analogue of the formula:
- where X is H, Br, Cl, F, CF3, or OCF3;
- or a pharmaceutically acceptable salt thereof.
A method for reducing bronchial hyperresponsiveness the method comprising administering to a mammal a therapeutically effective amount of a LFM analogue of the fonnula:
- where X is H, Br, Cl, F, CF3, or OCF3;
- or a pharmaceutically acceptable salt thereof.
A method for treating allergy comprising administering to a patient a therapeutically effective amount of a leflunomide analog of the formula:
- where X is H, Br, Cl, F, CF3, or OCF3;
- or a pharmaceutically acceptable salt thereof.
A method for treating anaphylactic shock comprising administering to a patient a therapeutically effective amount of a leflunomide analog of the formula:
- where X is H, Br, Cl, F, CF3, or OCF3;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.