Composition and method for prevention, reduction and treatment of radiation dermatitis

A method for the reduction or treatment of at least one adverse effect of radiation dermatitis caused by one or more types of radiation selected from the group consisting of alpha radiation, beta radiation, gamma ray radiation and fluoroscopic radiation, comprising the step of applying to an area of skin which has been or will be exposed to said one or more types of radiation, a topical composition which comprises:

• an amount of one or more compounds that inhibit at least one of cell differentiation and cell proliferation selected from the group consisting of vitamin D3;
• 1(S), 3(R)-dihydxoxy-20(R)-(1-ethoxy-5-ethyl-5-hydroxy-2-heptyn-1-yl)-9, 10-seco-pregna-5(Z), 7(E), 10(19)-triene;
• 1,25-dihydroxyvitamin D3, and pharmaceutically acceptable salts thereof, which is effective, when administered topically in the topical composition to inhibit at least one of cell differentiation and cell proliferation, and
• an effective amount of one or more antioxidants or pharmaceutically acceptable salts thereof,
• formulated in a pharmaceutically acceptable carrier for a topical composition.