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US 6,753,138 B1Granted
Use of prothymosin in the diagnosis and treatment of endometriosis
AssigneeReprogen, Inc.
InventorsPatrick A. Schneider, Cynthia K. French, Karen K. Yamamoto
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Abstract
Prothymosin expression is up-regulated in endometriotic tissue. This invention provides methods of diagnosing endometriosis by detecting up-regulation of a prothymosin gene product, and methods of treating endometriosis by down-regulating expression of prothymosin in ectopic or eutopic endometriotic tissue.
Claims32
A method for use in the diagnosis of endometriosis in a subject comprising the steps of:
- detecting a test amount of a prothymosin gene product in a sample from the subject;
- and
- comparing the test amount with a normal amount of the prothymosin gene product in a control sample,
- whereby a test amount above the normal amount provides a positive indication in the diagnosis of endometriosis.
1 more element
A method for use in the monitoring the progress of endometriosis in a subject comprising the steps of:
- detecting a first test amount of a prothymosin gene product in a sample from the subject at a first time;
- detecting a second test amount of the prothymosin gene product in a sample from the subject at a second, later time;
- and
- comparing the first test amount with the second test amount,
- whereby an increase in the amount between the first time and the second time indicates progression of endometriosis and a decrease in the amount between the first time and the second time indicates remission of endometriosis.
2 more elements
Dependencies are inferred from the claim text.