Substituted amino acids as erythropoietin mimetics
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsPeter J. Connolly, Victor T. Bandurco, Steven K. Wetter, Sigmond Johnson, Jacqueline Bussolari, William V. Murray
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Abstract
This invention relates to a series of substituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which bind to the erythropoietin receptor and compete with the natural ligand for binding to this receptor.
Claims17
A compound of the formula below:
- wherein
- R2 and R4 are both 4-t-Bu-PhO;
- R3, R5, R9, and Ra are all H;
- and
- n is 1 or 2.
A pharmaceutical composition comprising an active drug component and a compound of the formula
- wherein
- R2 and R4 are both 4-t-Bu-PhO;
- R3, R5, R9, and Ra are all H;
- and
- n is 1 or 2.
An oral composition comprising an EPO receptor modulating compound of the formula
- wherein
- R2 and R4 are both 4-t-Bu-PhO;
- R3, R5, R9, and Ra are all H;
- and
- n is 1 or 2;
- said composition having an active drug component being combined with an oral, non-toxic pharmaceutically acceptable inert carrier.
Dependencies are inferred from the claim text.