Humanized and chimeric N-terminal amyloid beta-antibodies
AssigneeNeuralab Limited
InventorsDale B. Schenk, Frederique Bard, Theodore Yednock
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Abstract
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit The methods are useful for prophylactic and therapeutic treatment of Alzheimer's disease. Preferred agents including N-terminal fragments of Aβ and antibodies binding to the same.
Claims12
A pharmaceutical composition comprising a chimeric or humanized antibody that specifically binds to an epitope within residues 1-10 of Aβ and a pharmaceutical carrier.
A diagnostic kit, comprising a chimeric or humanized antibody that specifically binds to an epitope within residues 1-10 of Aβ.
Dependencies are inferred from the claim text.