Film-forming agent for drug delivery and preparation for percutaneous administration containing the same
AssigneePacific Corporation
InventorsYoung So Kim, Yang Gyu Choi, Jung Ju Kim
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Abstract
The present invention relates to a film-forming agent which forms a film on the skin, and also to a preparation for percutaneous administration containing the film-forming agent and active ingredient. The transdermal preparation including the film-forming agent of the present invention and active ingredient exhibits excellent elasticity and flexibility, shows superior adhesion power when formed on the skin, and forms non-sticky film.
Claims19
A film-forming agent characterized in comprising 50˜99% by weight of the following polyurethane (A) and 1˜50% by weight of the following addition polymerization polymer (B) having a functional group of carboxylic acid derivative:
- (A) Polyurethane with weight average molecular weight of 10,000˜500,000, which is prepared by polymerization of the following ingredient (a-1), (a-2), and (a-3), and represented with the following formula 1:
- (a-1) polyethylene glycol;
- (a-2) polydiol with hydroxyl groups at both ends, which has stronger hydrophobicity than the said (a-1);
- and
- (a-3) diisocyanate having isocyanate at both ends
- and
- (B) The addition polymerization polymer with a functional group of carboxylic acid derivative has weight average molecular weight of 10,000˜800,000 which contains carboxylic acid alkyl ester and/or carboxylic acid alkyl amide and/or carboxylic acid alkyl amino alkyl ester on main chain or side chain.
Dependencies are inferred from the claim text.