Methods of treating disorders of the eye
AssigneeAcorda Therapeutics, Inc.
InventorsThomas A. Reh, Mark A. Marchionni, Kathryn L. McCabe, Olivia Bermingham-McDonogh, Nagesh K. Mahanthappa, David I. Gwynne
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Abstract
In general, the present invention provides methods for promoting the function of retinal cells using neuregulins. A novel aspect of the invention involves the use of neuregulins as growth factors tp promote survival of retinal cells. Treating of the retinal cells to provide these effects may be achieved by contacting retinal cells with a polypeptide described herein. The treatments may be provided to slow or halt net cell loss or to increase the amount or quality of retinal tissue present in the vertebrate.
Claims21
A method for the treatment of a pathophysiological condition of retinal cells of a mammal, wherein said pathophysiological condition is selected from the group consisting of a retinopathy, hypertensive retinopathy, diabetic retinopathy, occlusive retinopathy, retinal degeneration, retinal degeneration caused by injury, retinal degeneration caused by a genetic disorder, retinal degeneration by retinitis pigmentosa, and retinal degeneration caused by age related macular degeneration, or is caused by elevated intraocular pressure or an optic neuropathy, or involves retinal cell damage, said method comprising administering to said mammal a therapeutically effective amount of human glial growth factor 2 polypeptide (SEQ. ID. NO.:
- 65).
Dependencies are inferred from the claim text.