Chlorination of an aniline in a hydrofluoric medium
AssigneeRhodia Chimie
InventorsHubert Kempf, Gilbert Guidot, Laurent Saint-Jalmes
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Abstract
The invention concerns a method for the synthesis of chlorinated aniline on the ring and comprising at least a sp3 hybridization carbon atom both perhalogenated and bearing a fluorine atom. Said method is characterized in that it comprises a step which consists in chlorinating a precursor aniline of said chlorinated aniline, said chlorination being carried out in a hydrofluoric medium capable of exchanging chlorine and fluorine in benzyl position. The invention is useful for the synthesis of organofluorinated and/or chlorinated compounds.
Claims9
A process for the preparation of an aniline compound chlorinated on the ring, and having at least one carbon atom of sp3 hybridization, which is perhalogenated and carries a fluorine atom, said process comprising the step of chlorination of a precursor aniline compound, in a hydrofluoric acid medium capable of exchanging a chlorine atom and a fluorine atom in a benzyl position or on said carbon atom of sp3 hybridization carrying a chalcogen atom, said precursor aniline compound being of the formula:
- wherein:
- Z represents a single bond or the chalcogen atom;
- X1, X2, and X3 represent identical or different halogens, with the further proviso that at least two halogens are other than fluorine;
- and
- R1 and R2 are halogens, alkyls, aryls or nitriles.
Dependencies are inferred from the claim text.