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US 6,747,128 B2Granted
Components of ubiquitin ligase complexes, and uses related thereto
AssigneeGPC Biotech AG
InventorsMaureen Caligiuri, Mark Rolfe
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AssigneeGPC Biotech AG
InventorsMaureen Caligiuri, Mark Rolfe
Estimating the term…
The present invention relates to the isolation of a new class of ubiquitin ligases involved in protein degradation in vertebrate organisms, such as protein degradation of cell cycle regulatory proteins. Accordingly, the invention provides nucleic acids and the proteins encoded by said nucleic acids which play a role in the ubiquitinylation and subsequent degradation of substrate proteins and in regulating cell proliferation, cell differentiation, and cell survival. The invention also provides methods for modulating protein degradation, cell proliferation, cell differentiation and/or cell survival by modulating protein ubiquitination; assays for identifying compounds which modulate protein degradation, cell proliferation, differentiation and/or cell survival; methods for treating disorders associated with aberrant protein degradation, cell proliferation, cell differentiation, and/or cell survival; and diagnostic and prognostic assays for determining whether a subject is at risk of developing a disorder associated with an aberrant protein degradation, cell proliferation, cell differentiation, and/or survival.
An isolated nucleic acid comprising a nucleotide sequence encoding a polypeptide, or a nucleotide sequence complementary thereto, wherein said polypeptide comprises an amino acid sequence at least 95% identical to the amino acid sequence set forth in SEQ ID NO:
An isolated nucleic acid comprising a nucleotide sequence encoding a polypeptide that is at least 95% identical to an amino acid sequence of SEQ ID NO:
An isolated nucleic acid comprising a nucleotide sequence encoding a polypeptide, or a nucleotide sequence complementary thereto, wherein said polypeptide comprises an amino acid sequence at least 95% identical to the amino acid sequence set forth in SEQ ID NO:
An isolated nucleic acid comprising a nucleotide sequence encoding a polypeptide, or a nucleotide sequence complementary thereto, wherein said polypeptide comprises an amino acid sequence at least 95% identical to a portion of SEQ ID NO:
An isolated nucleic acid comprising the nucleotide sequence set forth in SEQ ID NO:
Dependencies are inferred from the claim text.