Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators

A compound represented by the general formula (I):

• wherein A1 is an amino acid residue selected from the group consisting of cyclohexylalanine, Leu, Ile, Arg, Lys, Phe, substituted Phe, Tyr and Trp;
• A2 is an amino acid residue selected from the group consisting of Lys, Orn, Arg, and homo Arg;
• A3 is an amino acid residue selected from the group consisting of Phe, substituted Phe, homo Phe, Tyr, Trp, phenylglycine, 2-thienylalanine, 3-thienylalanine, cyclohexylalanine, Leu, Ile, Asn, Gin, Arg, homo Arg, Orn and Lys;
• X is selected from the group consisting of CO, CS, and SO2;
• Y is selected from the group consisting of aryl, substituted aryl, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, heteroarylethylenyl, substituted heteroarylethylenyl, arylacrylamidoheteroaryl, substituted arylacrylamidoheteroaryl, heteroarylacrylamidoheteroaryl and substituted heteroarylacrylamidoheteroaryl, provided that Y is not pyrrolidinyl, phenyl or 2-aminophenyl;
• Z is selected from the group consisting of NH2, NH-alkyl, NH-aralkyl, and Arg-NH2;
• and
• wherein all amino acids are of the L configuration;
• and any pharmaceutically acceptable salt thereof.