Peptide inhibitors of HIV entry
AssigneeWhitehead Institute for Biomedical Research
InventorsDebra M. Eckert, Tara R. Suntoke, Peter S. Kim
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Abstract
Described herein are chimeric peptides comprising a soluble trimeric coiled-coil and all or a portion of the N-peptide region of HIV gp41. These molecules are stable, trimeric coiled-coils that inhibit HIV entry into cells, such as human cells. Such peptides can be further assessed to demonstrate their ability to serve as potent anti-HIV therapeutic molecules and thus, as therapeutic molecules or drugs.
Claims2
A soluble trimeric coiled-coil peptide comprising a peptide:
- IQN26, wherein the amino acid sequence of IQN26 is:
- (SEQ ID NO:13) Ac-R M K Q I E D K I E E I Arg Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile E S K Q Y K I E N E I A Glu Ser Lys Gln Tyr Lys Ile Glu Asn Glu Ile Ala R I K K L I V Q A R Q L Arg Ile Lys Lys Leu Ile Val Gln Ala Arg Gln Leu L S G I V Q Q Q N N L L Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu R A I E A Q Q H -CONH2;
- Arg Ala Ile Glu Ala Gln Gln His
A soluble trimeric coiled-coil peptide consisting of a peptide IQN26, wherein the amino acid sequence of IQN26 is:
- (SEQ ID NO:13) Ac-R M K Q I E D K I E E I Arg Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile E S K Q Y K I E N E I A Glu Ser Lys Gln Tyr Lys Ile Glu Asn Glu Ile Ala R I K K L I V Q A R Q L Arg Ile Lys Lys Leu Ile Val Gln Ala Arg Gln Leu L S G I V Q Q Q N N L L Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu R A I E A Q Q H -CONH2. Arg Ala Ile Glu Ala Gln Gln His
Dependencies are inferred from the claim text.