Poly(L-lactide-co-glycolide) copolymers, methods for making and using same, and devices containing same
AssigneeSynthes USA, LLC
InventorSylwester Gogolewski
Life of this patent
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Abstract
The present invention relates in general to implantable, resorbable copolymers containing L-lactide and glycolide repeat units, and in particular to terpolymers containing L-lactide, glycolide, and one other type of repeat unit selected from the group consisting of D-lactide, D,L-lactide, and ε-caprolactone. Medical devices for in vivo implantation applications containing such implantable, resorbable copolymers are also described, as well as methods for making such copolymers and devices.
Claims34
An implantable medical device comprising a terpolymer having repeat units of L-lactide, D-lactide, and glycolide and that is made by the process comprising:
- contacting dimers or a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, D-lactide, and glycolide to form a dimer or monomer-dimer mixture, wherein at least a portion of the L-lactide repeat units are supplied by L-lactide dimers or by L-lactic acid monomers;
- polymerizing substantially all of the dimer or monomer-dimer mixture to form the terpolymer.
An implantable medical device comprising a terpolymer having repeat units of L-lactide, D,L-lactide, and glycolide and that is made by the process comprising:
- contacting dimers or a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, D,L-lactide, and glycolide to form a dimer or monomer-dimer mixture, wherein at least a portion of the L-lactide repeat units are supplied by L-lactide dimers or by L-lactic acid monomers;
- polymerizing substantially all of the dimer or monomer-dimer mixture to form the terpolymer.
An implantable medical device consisting essentially of a terpolymer having repeat units of about 80% L-lactide, about 10% ε-caprolactone, and about 10% glycolide and that is made by the process comprising:
- contacting a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, ε-caprolactone, and glycolide to form a monomer-dimer mixture;
- and
- polymerizing substantially all of the monomer-dimer mixture to form the terpolymer.
An implantable medical device comprising a terpolymer having repeat units depicted by the following formula:
- wherein the repeat unit having subscript x is an L-lactide repeat unit, the third component having subscript y is a D-lactide repeat unit;
- the molar percentages of the repeating units are such that x is from about 0.75 to about 0.9, y is from about 0.02 to about 0.16, and z is from about 0.04 to about 0.18;
- and x+y+z=1;
- and
- wherein the terpolymer is made by the process comprising:
- contacting dimers or a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, glycolide, and either D-lactide or D,L-lactide, to form a dimer or monomer-dimer mixture, wherein at least a portion of the L-lactide repeat units are supplied by L-lactide dimers or by L-lactic acid monomers;
- polymerizing substantially all of the dimer or monomer-dimer mixture to form the terpolymer.
A terpolymer comprising from about 75% to about 90% L-lactide repeat units, from about 4% to about 11% D-lactide repeat units, and from about 4% to about 18% glycolide repeat units, wherein the terpolymer is made by the process comprising:
- contacting dimers or a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, D-lactide, and glycolide to form a dimer or monomer-dimer mixture, wherein at least a portion of the L-lactide repeat units are supplied by L-lactide dimers or by L-lactic acid monomers;
- polymerizing substantially all of the dimer or monomer-dimer mixture to form the terpolymer.
A terpolymer comprising about 80% L-lactide repeat units, about 10% repeat units from ε-caprolactone, and about 10% glycolide repeat units, wherein the terpolymer is made by the process comprising:
- contacting a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, ε-caprolactone, and glycolide to form a monomer-dimer mixture;
- polymerizing substantially all of the monomer-dimer mixture to form the terpolymer.
A terpolymer comprising at least about 50% L-lactide repeat units, from about 1% to about 20% D,L-lactide repeat units, and from about 1% to about 30% glycolide repeat units, wherein the terpolymer is made by the process comprising:
- contacting dimers or a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, D,L-lactide, and glycolide to form a dimer or monomer-dimer mixture, wherein at least a portion of the L-lactide repeat units are supplied by L-lactide dimers or by L-lactic acid monomers;
- polymerizing substantially all of the dimer or monomer-dimer mixture to form the terpolymer.
Dependencies are inferred from the claim text.