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US 6,747,064 B2Granted
Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
AssigneeCytRx Corporation
InventorsR. Martin Emanuele, Robert L. Hunter, Paula H. Culbreth
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Abstract
The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
Claims6
A method for reducing pathologic hydrophobic interactions, comprising:
- administering to a patient at risk for cell damage a composition comprising a substantially pure polyoxypropylene/polyoxyethylene block copolymer composition, wherein said substantially pure polyoxypropylene/polyoxyethylene block copolymer composition is substantially free of unsaturated molecules, said substantially pure polyoxypropylene/polyoxyethylene block copolymer composition containing block copolyrmers with each of the block copolymers having the following general formula:
- HO(C2H4O)b(C3H6O)a(C2H4O)bH
- wherein a is an integer such that the molecular weight represented by the polyoxypropylene portion of the respective block copolymer is between 900 Daltons and 15,000 Daltons, and b is an integer such that the molecular weight represented by the polyoxyethylene portion of the respective block copolymer constitutes between 5% and 95% of the respective block copolymer, and the polydispersity value is less than approximately 1.07, and whereby pathologic hydrophobic interactions are reduced by the restoration or maintenance of non-adhesive cell surfaces by the block copolymers.
A method for reducing pathologic hydrophobic interactions, comprising:
- administering to a patient at risk for cell damage a composition comprising a substantially pure polyoxypropylene/polyoxyethylene block copolymer composition, wherein said substantially pure polyoxypropylene/polyoxyethylene block copolymer composition is prepared by
- (a) providing a non-purified polyoxypropylene/polyoxyethylene block copolymer composition prepared by first polymerizing propylene oxide and thereafter copolymerizing ethylene oxide therewith which results in the formation of at least
- (1) block copolymers with each of the block copolymers having the following general formula:
- HO(C2H4O)b(C3H6O)a(C2H4O)bH
- wherein a is an integer such that the molecular weight represented by the polyoxypropylene portion of the respective block copolymer is between 900 Daltons and 15,000 Daltons, and b is an integer such that the molecular weight represented by the polyoxyethylene portion constitutes between 5% and 95% of the respective block copolymer, and
- (2) at least one impurity resulting from the manufacture of the non-purified block copolymer composition, wherein the at least one impurity contains unsaturation and,
- (b) substantially removing the at least one impurity from the non-purified block copolymer composition resulting in said substantially pure polyoxypropylene/polyoxyethylene block copolymer composition which thereby has the property of having less unsaturation than the non-purified copolymer composition from which said substantially pure polyoxypropylene/polyoxyethylene block copolymer composition is derived, said substantially pure polyoxypropylene/polyoxyethylene block copolymer composition containing block copolymers with each of the block copolymers having the following general formula:
- HO(C2H4O)b(C3H6O)a(C2H4O)bH
- wherein a is an integer such that the molecular weight represented by the polyoxypropylene portion of the respective block copolymer is between 900 Daltons and 15,000 Daltons, and b is an integer such that the molecular weight represented by the polyoxyethylene portion of the respective block copolymer constitutes between 5% and 95% of the respective block copolymer, and the polydispersity value is less than approximately 1.07;
- and whereby pathologic hydrophobic interactions are reduced by the restoration or maintenance of non-adhesive cell surfaces by the block copolymers.
7 more elements
Dependencies are inferred from the claim text.