Composition for, and methods of, anti-platelet therapy
AssigneeMars, Incorporated
InventorsLeo J. Romanczyk, Jr., Harold H. Schmitz
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Abstract
Cocoa extracts which include procyanidin monomers and their oligomers are useful in the modulation of inflammatory pathways, in the maintenance of the vascular health of a mammal and as an antibacterial treatment. The liquid or dry cocoa extracts can be included in foods, food supplements and pharmaceuticals for the inhibition of COX activity, the inhibition of LOX activity, the enhancement of nitric oxide production, the modulation of eicosanoids and endothelin, and the modulation of platelet activity.
Claims11
A method of anti-platelet therapy or prophylaxis comprising administering to a subject in need thereof a composition comprising an effective amount of a cocoa procyanidin monomer and/or oligomer and a carrier selected from the group consisting of a pharmaceutically acceptable carrier, veterinary acceptable carrier, dietary supplement carrier and food, wherein said subject is a human or a veterinary animal, and wherein the cocoa procyanidin monomer is of the formula:
- and the cocoa procyanidin oligomer is composed of the monomers connected via interflavan linkages 4→6 and/or 4→8.
Dependencies are inferred from the claim text.