K99-5041 substance and production thereof
AssigneeThe Kitasato Institute
InventorsSatoshi Omura, Hiroshi Tomoda, Yoko Takahashi, Yutaka Ebizuka, Masaaki Shibuya
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Abstract
The present invention comprising culturing a microorganism which belongs to genus Streptomyces and has ability to produce K99-5041-C1x substance and/or K99-5041-C2x substance in a medium, accumulating K99-5041-C1x substance and/or K99-5041-C2x substance in the culture fluid, and isolating K99-5041-C1x substance and/or K99-5041-C2x substance form the cultured mass. Since the obtained K99-5041-C1x substance and/or K99-5041-C2x substance exhibit inhibitory activity against lanosterol synthase, these substances are expected to apply clinically for preventive and therapeutic agents caused by accumulation of cholesterol in humans and antifungal agents.
Claims12
K99-5041-C1x substance represented by the following Formula [I]:
K99-5041-C2x substance represented by the following formula [II]:
A medicament of K99-5041 substance comprising K99-5041-C1x substance represented by the following formula [I]:
- and K99-5041-C2x substance represented by the following formula [II]:
A medicament comprising K99-5041-C1x substance represented by the following formula [I]:
- or K99-5041-C2x substance represented by the following formula [[II]]
Dependencies are inferred from the claim text.