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US 6,747,046 B2Granted
Substituted N-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl) derivatives, their production and use as pharmaceutical agents
AssigneeSchering Corporation
InventorsMartin Krüger, Olaf Prien, Andreas Steinmeyer, Jörg Kroll, Alexander Ernst, Gerhard Siemeister, Martin Haberey, Jens Hoffmann
Life of this patent
Estimating the term…
Abstract
Substituted N-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl) derivatives, their production, as well as intermediate products for their production, and the use as pharmaceutical agents for treating various diseases are described.
Claims9
Compounds of general formula I,
- wherein
- R1 stands for linear or branched C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C1-C6-alkoxy, C1-C6-alkylthio or C3-C12-cycloalkyl, C3-C12-cycloalkenyl, C3-C12-heterocycloalkyl, C3-C12-heterocycloalkenyl, aryl or heteroaryl, which optionally can be substituted,
- R2 and R3 are the same or different and stand for hydrogen, linear or branched C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl or C1-C6-alkoxy, which optionally can be substituted,
- R4 and R5 are the same or different and stand for hydrogen, halogen, linear or branched C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl or C1-C6-alkoxy, which optionally can be substituted, or together stand for a carbonyl group, or together form a cyclic five- or six-ring-acetal with O,O;
- N,O;
- O,S;
- or S,S, which optionally can be substituted with C1-C6-alkyl, or
- R2 and R4 together form a C3-C12-cycloalkyl ring or a C3-C12-cycloalkenyl ring, which optionally can be substituted,
- R6 and R7 are the same or different and stand for hydrogen, linear or branched C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkinyl, which optionally can be substituted, or together form a C3-C12-cycloalkyl ring or a C3-C12-cycloalkenyl ring, which optionally can be substituted, or
- R5 and R6 optionally together form a double bond, or
- R3 and R5 together form a C3-C12-cycloalkyl ring or a C3-C12-cycloalkenyl ring, which optionally can be substituted,
- T stands for —CH2—, —O—, —CH2═CH2—, —CH≡CH—, —CH2—O—CH2—, —CH2—O—, —O—CH2— or ═CO, and
- n stands for 0-6, or a tautomer, isomer or salt thereof.
10 more elements
Dependencies are inferred from the claim text.