(Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties

A compound of formula (I)

• a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein
• Alk1 is C1-4alkylcarbonyl, C1-4alkylcarbonylC1-4alkyl, carbonyl, carbonylC1-4alkyl, or C1-6alkanediyl optionally substituted with hydroxy, C1-4alkyloxy, C1-4akylcarbonyloxy, C1-4akylcarbonyloxyC1-4alkyloxycarbonyloxy, or C3-6cycloalkylcarbonyloxyC1-4alkyloxycarbonyloxy;
• —Z1—Z2— is a bivalent radical of formula
• —CH2— (e-1), —O—CH2— (e-2), —S—CH2— (e-3), —CH2—CH2— (e-4), —CH2—CH2—CH2— (e-5), —CH═ (e-6), —CH2—CH═ (e-7), —CH2—CH2—CH═ (e-8), —CH═CH— (e-9);
• R1, R2 and R3 are each independently selected from hydrogen, C1-6alkyl, C3-6alkenyl, C1-6alkyloxy, trihalomethyl, trihalomethoxy, halo, hydroxy, cyano, nitro, amino, C1-6alkylcarbonylamino, C1-6alkyloxycarbonyl, C1-4alkylcarbonyloxy, aminocarbonyl, mono- or di-(C1-6alkyl)aminocarbonyl, aminoC1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, C1-4alkylcarbonyloxy-C1-4alkyloxycarbonyloxy, or C3-6cycloalkylcarbonyloxyC1-4alkyloxy-carbonyloxy;
• or
• when R1 and R2 are on adjacent carbon atoms, R1 and R2 taken together may form a bivalent radical of formula
• —CH2—CH2—CH2— (a-1), —CH2—CH2—CH2—CH2— (a-2), —CH2—CH2—CH2—CH2—CH2— (a-3), —CH═CH—CH═CH— (a-4), —O—CH2—O— (a-5), —O—CH2—CH2— (a-6), —O—CH2—CH2—O— (a-7), —O—CH2—CH2—CH2— (a-8), —O—CH2—CH2—CH2—CH2— (a-9),
• wherein optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by hydroxy, C1-4alkyl or CH2OH;
• R4 is hydrogen, C1-6alkyl, or a direct bond when the bivalent radical —Z1—Z2— is of formula (e-6), (e-7) or (e-8);
• A is a bivalent radical of formula
• wherein the nitrogen atom is connected to Alk1 and,
• m is 0 or 1;
• Alk2 is C1-6alkanediyl;
• R6 is hydrogen, C1-6alkyl, C1-4alkylcarbonyl, C1-4alkyloxycarbonyl, phenylmethyl, C1-4alkylaminocarbonyl, C1-4alkylcarbonyloxy-C1-4alkyloxycarbonyl, or C3-6cycloalkylcarbonyloxyC1-4alkyloxycarbonyloxy;
• R5 is a radical of formula
• wherein n is 1 or 2;
• X is oxygen, sulfur, NR9 or CHNO2;
• Y is oxygen or sulfur,
• R7 is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl;
• R8 is C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl;
• R9 is cyano, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxycarbonyl or aminocarbonyl;
• R10 is hydrogen or C1-6alkyl;
• and
• Q is a bivalent radical of formula
• —CH2—CH2— (d-1), —CH2—CH2—CH2— (d-2), —CH2—CH2—CH2—CH2— (d-3), —CH═CH— (d-4), —CH2—CO— (d-5), —CO—CH2— (d-6),
• wherein optionally one or two hydrogen atoms on the same or a different carbon atom may be replaced by C1-4alkyl, hydroxy or phenyl.