N-heterocyclic derivatives

A compound having formula (I):

• and pharmaceutically acceptable derivatives thereof, wherein:
• X is O;
• A is phenyl
• B is hydrogen;
• wherein 1 to 4 hydrogen atoms in A are optionally and independently replaced with halogen, hydroxyl, hydroxymethyl, nitro, SO3H, trifluoromethyl, trifluoromethoxy, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl, O—[(C1-C6)-straight or branched alkyl], O—[(C3-C6)-straight or branched alkenyl], (CH2)n—N(R4)(R5), (CH2)n—NH(R4)—(CH2)n—Z, (CH2)n—N(R4—(CH2)n—Z)(R5—(CH2)n—Z), (CH2)n—Z, O—(CH2)n—Z, (CH2)nO—Z, S—(CH2)n—Z, CH═CH—Z, 1,2-methylenedioxy, C(O)OH, C(O)O—[(C1-C6)-straight or branched alkyl], C(O)O—(CH2)n—Z or C(O)—N(R4)(R5);
• wherein each of R4 and R5 are independently hydrogen, (C1-C6)-straight or branched alkyl, (C3-C5)-straight or branched alkenyl, or wherein R4 and R5, when bound to the same nitrogen atom, are taken together with the nitrogen atom to form a 5 or 6 membered ring, wherein said ring optionally contains 1 to 3 additional heteroatoms independently selected from N, O or S;
• wherein said alkyl, alkenyl or alkynyl groups in R4 and R5 are optionally substituted with Z.
• each n is independently 0 to 4;
• each Z is independently selected from a saturated, partially saturated or unsaturated, monocyclic or bicyclic ring system, wherein each ring contains 5 to 7 ring atoms independently selected from C, N, O or S;
• and wherein no more than 4 ring atoms are selected from N, O or S;
• wherein 1 to 4 hydrogen atoms in Z are optionally and independently replaced with halo, hydroxy, nitro, cyano, C(O)OH, (C1-C3)-straight or branched alkyl, O—(C1-C3)-straight or branched alkyl, C(O)O—[(C1-C3)-straight or branched alkyl], amino, NH[C1-C3)-straight or branched alkyl], or N—[(C1-C3)-straight or branched alkyl]2;
• K is hydrogen
• J and D are taken together with the nitrogen atom, form 1,2,3,4-tetrahydroisoquinolin-2-yl ring;
• wherein 1 to 4 hydrogen atoms in said ring are optionally and independently replaced with (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl or alkynyl, oxo, hydroxyl or Z.